Journal
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
Volume 17, Issue 12, Pages 1011-1041Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14787210.2019.1694905
Keywords
Phage; phage resistance; endolysin; phage therapy; phagotherapy
Funding
- [UM1 AI104681]
- [R01 AR056647]
- [R01 AI091594]
- [R01 AI134770]
- [R21 AI125870]
- [T32 AR056950]
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Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans. Areas covered: This review assessed the scientific literature on phage therapy published between 1 January 2007 and 21 October 2019, with a focus on the successes and challenges of this prospective therapeutic. Expert opinion: Efficacy has been shown in animal models and experimental findings suggest promise for the safety of human phagotherapy. Significant challenges remain to be addressed prior to the standardization of phage therapy in the West, including the development of phage-resistant bacteria; the pharmacokinetic complexities of phage; and any potential human immune response incited by phagotherapy.
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