Journal
EXPERIMENTAL NEUROLOGY
Volume 328, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2020.113273
Keywords
Animal model; Animal welfare; Refinement; Three Rs; Spinal cord injury; Spinal contusion; Spinal transection; Paralysis; Translational research; Regeneration; Tissue repair
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This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.
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