Journal
EUROPEAN POLYMER JOURNAL
Volume 125, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2020.109505
Keywords
Nanogel; Dextran; Glucose sensing; Insulin delivery
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Funding
- Science and Technology program of Zhejiang Province [2019C030637]
- Fundamental Research Funds for the Central Universities [2019FZA4022]
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Different glucose-responsive nanogels of N-isopropylacrylamide (NIPAM) and 4-(1,6-dioxo-2,5-diaza-7-oxamyl) phenylboronic acid (DDOPBA) were synthesized using dextran-grafted maleic acid (Dex-MA) as a crosslinker. The formed nanogels (P(NIPAM-co-Dex-co-DDOPBA)s) were verified by H-1 NMR, TEM, DLS and X-ray photoelectron spectroscopy (XPS). The incorporation of DDOPBA provided a remarkable sensitivity towards glucose in physiological pH due to the existence of electron-withdrawing group in its structure. Similarly, the hydrophilic Dex-MA modulated the temperature-sensitivity near physiological temperature. The nanogels exhibited high insulin loading capacity and encapsulation efficiency and the in vitro release profiles demonstrated a glucose dependant release of the payload at physiological pH and temperature.
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