Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 870, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2019.172888
Keywords
Dihydromyricetin; Ampelopsin; Diabetes mellitus; Atherosclerosis; Nonalcoholic fatty liver disease; Osteoporosis
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Dihydromyricetin (DMY or DHM), also known as ampelopsin, is the main natural flavonol compound extracted from the plant Ampelopsis grossedentata (Hand. -Mazz) W.T. Wang. In recent years, accumulating studies have been conducted to explore the extensive biological functions of DMY, including antitumor, anti-inflammation, organ-protective, and metabolic regulation effects. DMY acts as a potential preventive or therapeutic agent in treating multiple diseases, such as diabetes mellitus, atherosclerosis, nonalcoholic fatty liver disease and osteoporosis. This review article summarizes the preventive and therapeutic potential of DMY in multiple metabolic diseases and the main signaling pathways in which DMY participates to offer a comprehensive understanding and guidance for future studies.
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