Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 866, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2019.172810
Keywords
Myocardial infarction; Exercise intolerance; Mitochondria; SGLT2 inhibitor; Ketone body; Muscle strength
Categories
Funding
- Japan Foundation for Applied Enzymology
- Hokkaido Heart Association Grant for Research
- MSD Life Science Foundation
- Uehara Memorial Foundation
- Cardiovascular Research Fund, Tokyo, Japan
- Fukuda Memorial Foundation for Medical Research
- Kimura Memorial Heart Foundation Research Grant for 2017
- SENSHIN Medical Research Foundation
- Nakatomi Foundation
- Japan Heart Foundation
- Sasakawa Scientific Research Grant from The Japan Science Society
- Center of Innovation Program from the Japan Science and Technology Agency
- [JP17K15979]
- [JP17K10137]
- [JP17H04758]
- [18H03187]
- [19K22791]
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Decreased exercise capacity, which is an independent predictor of the poor prognosis of patients with heart failure (HF), is attributed to markedly impaired skeletal muscle mitochondrial function and fatty acid oxidation. Previous studies reported that the administration of an inhibitor of sodium-glucose cotransporter 2 (SGLT2) increases ketone body production and fat utilization in type 2 diabetic mice. In this study, we investigated the effects of SGLT2 inhibitor administration on exercise endurance and skeletal muscle mitochondrial function with fatty acid oxidation in a murine model of HF after the induction of myocardial infarction (MI). Two weeks post-MI, HF mice were divided into 2 groups, i.e., with or without treatment with the SGLT2 inhibitor empagliflozin (Empa, 300 mg/kg of food). Consistent with previous studies, urinary glucose and blood beta-hydroxybutyrate levels were increased in the HF + Empa mice compared with the sham and HF mice 4 weeks after the start of Empa administration. Exercise endurance capacity was limited in the HF mice but was ameliorated in the HF + Empa mice, without any effects on cardiac function, food intake, spontaneous physical activity, skeletal muscle strength, and skeletal muscle weight. Mitochondrial oxidative phosphorylation capacity with fatty acid substrates was reduced in the skeletal muscle of HF mice, and this decrease was ameliorated in the HF +Empa mice. Our results demonstrate that SGLT2 inhibitors may be novel therapeutics against reduced exercise endurance capacity in HF, by improving mitochondrial fatty acid oxidation in skeletal muscle.
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