Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 865, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2019.172747
Keywords
Nucleosides; Nucleotides; Prodrugs; Antiviral therapy; Chain termination; Antineoplastic agents
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Nucleos(t)ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum activity towards multiple life-threatening RNA and DNA viruses. We also present a discussion about nucleoside antimetabolites-approved antineoplastic agents-that have recently been shown to have antiviral and/or antibacterial activity. The approved drugs and drug combinations, as well as recently identified candidates for investigation and/or experimentation, are discussed. Several examples of repurposed drugs that have already been approved for use are presented. This strategy can be crucial for the first-line treatment of acute infections or coinfections and for the management of drug-resistant strains.
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