Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2020, Issue 29, Pages 4447-4462Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201901840
Keywords
Reductive amination; Iminosugars; Carbohydrates; Polyhydroxylated piperidines; Glycosidase inhibitors; Pharmacological chaperones
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Funding
- MIUR-Italy
- Fondazione Cassa di Risparmio di Pistoia e Pescia (Bando Giovani@Ricerca scientifica 2017)
- Fondazione Cassa di Risparmio di Firenze [2018/0942]
- Fondazione CRF/University of Florence
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The reductive amination (RA) reaction plays a pivotal role in the synthesis of new C-N bonds, due to the availability of many different and low-cost reagents and their operational simplicity. The introduction in a compound of a nitrogen-containing moiety that can be reduced to an amine in the reaction medium allows to perform cascade reactions which further expand this method. The application of the intramolecular version of the RA to carbohydrates allows the synthesis of polyhydroxypiperidine iminosugars, which are among the most challenging and fascinating glycomimetics for a synthetic chemist. This minireview focuses on the use of RA and of the double reductive amination (DRA) reaction in the key ring-closing step en route to the synthesis of these compounds.
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