Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 184, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.111743
Keywords
Membrane-active molecules; Cationic amphiphilic compounds; Antibacterial agents; Bacterial resistance
Categories
Funding
- National Natural Science Foundation of China [81973179, 81673284]
- Key Research and Development Project of Shandong Province [2017CXGC1401]
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The continuous emergence of drug-resistant bacteria has become a severe threat to the public health. Therefore, the discovery of novel antibacterial mechanisms to combat this jeopardized problem is urgently needed. In the past decades, plenty of new antibacterial modes of action have been discovered continuously, based on which many promising scaffolds have been designed and synthesized. In particular, cationic amphiphilic small-molecules open a door to the new mode of action of bactericidal agents by depolarizing and disturbing the bacteria membrane. The cationic amphiphilic are characterized by high efficacy, resistant-proof, wide-spectrum, and high selectivity toward bacteria. In this review, we summarized recent advances in the discovery of membrane-active small-molecules and their structure-activity relationships (SARs), hoping to provide an evidence for future research and development of new antibacterial agents with new mechanism. (C) 2019 Elsevier Masson SAS. All rights reserved.
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