Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 50, Issue 3, Pages 317-325Publisher
WILEY
DOI: 10.1002/eji.201848054
Keywords
Candida albicans; CARD9; C-type lectin receptors; dectin-1; dectin-2
Categories
Funding
- National Institutes of Health [R01AI121066, R01DK115217, NIAID-DAIT-NIHAI201700100]
- Associazione Italiana per la Ricerca sul Cancro [IG 2016Id.18842]
- Cariplo Foundation [2014-0655]
- Fondazione Regionale per la Ricerca Biomedica, FRRB
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Humans are constantly exposed to fungi, either in the form of commensals at epithelial barriers or as inhaled spores. Innate immune cells play a pivotal role in maintaining commensal relationships and preventing skin, mucosal, or systemic fungal infections due to the expression of pattern recognition receptors that recognize fungal cell wall components and modulate both their activation status and the ensuing adaptive immune response. Commensal fungi also play a critical role in the modulation of homeostasis and disease susceptibility at epithelial barriers. This review will outline cellular and molecular mechanisms of anti-fungal innate immunity focusing on C-type lectin receptors and their relevance in the context of host-fungi interactions at skin and mucosal surfaces in murine experimental models as well as patients susceptible to fungal infections.
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