Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 50, Issue 5, Pages 685-694Publisher
WILEY
DOI: 10.1002/eji.201948423
Keywords
autoimmune disease; HERV-W; leukocytes; multiple sclerosis; syncytin
Categories
Funding
- REEM: Red Espanola de Esclerosis Multiple [RD16/0015/0013]
- ISCIII-Feder [PI15/00821, PI18/00204]
- Fundacion Ramon Areces [CIVP18A3860]
- Fundacion LAIR
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Syncytin-1 is the envelope protein of the human endogenous retrovirus W (HERV-W). It has been related to multiple sclerosis (MS) but its role in cellular immunity and its pathogenic mechanism in the autoimmune context are not fully understood. We analyzed syncytin-1 levels in peripheral blood mononuclear cells (PBMC) subsets from healthy donors, MS patients in relapse or remission, and patients with acute infections by flow cytometry. PBMC cultures were also prepared to analyze protein expression kinetics. MS patients had higher levels of syncytin-1 levels than controls. We found that syncytin-1 is elevated in monocytes during MS relapses and infections. Cells expressing syncytin-1, including monocytes, T and B lymphocytes, and NKs presented mainly an activated phenotype and, upon stimulation with LPS, its levels increased rapidly on antigen-presenting cells. Syncytin-1 ligation promoted the activation of monocytes, as demonstrated by the upregulation of CD80 and the nonclassical subset CD14(low) CD16(+). Our results suggest an important role for syncytin-1 in the activation of leukocytes. Given that the expression of syncytin-1 is upregulated in MS patients, this protein might be contributing to the autoimmune cascade in the disease.
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