Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 50, Issue 4, Pages 606-609Publisher
WILEY
DOI: 10.1002/eji.201848051
Keywords
chronic myeloid leukemia; extracellular vesicles; Foxp3; immunosuppression; regulatory T cells
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Funding
- National Science Centre [UMO-2013/10/E/NZ3/00673, UMO-2018/29/N/NZ3/01754]
- Foundation for Polish Science grant TEAM TECH Core Facility Plus/2017-2/2 (European Union under the European Regional Development Fund) [POIR.04.04.00-00-23C2/17-00]
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Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis.
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