Journal
ENVIRONMENTAL TOXICOLOGY
Volume 35, Issue 6, Pages 697-706Publisher
WILEY
DOI: 10.1002/tox.22905
Keywords
beta-catenin; glioma; stemness; TRIB3; Wnt
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Here, we aim to explore whether tribbles pseudokinase 3 (TRIB3) enhances glioma cell stemness. TRIB3 was overexpressed in glioma tissues and cell-formed spheres, positively correlated with the size and grade. Additionally, TRIB3 expression displayed a negative correlation with the overall survival rate of glioma patients. Moreover, TRIB3 knockdown reduced the stemness of nonadherent spheres, evident by the decreased sphere-forming ability, stemness master expression, and ALDH1 activity, while TRIB3 overexpression enhanced the stemness of adherent cells, which was rescued by beta-catenin knockdown. Mechanistically, TRIB3 activated beta-catenin signaling via physically interacting with beta-catenin. This study suggests that the TRIB3-beta-catenin interaction is responsible for glioma cell stemness.
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