Journal
ENVIRONMENTAL POLLUTION
Volume 255, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2019.113261
Keywords
Oxy-PAHs; Metastasis; EMT; DNA methylation; Histone acetylation
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Funding
- National Science Foundation of China [21677091]
- Program for the Top Young Academic Leaders of Higher Learning Institutions of Shanxi
- Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi
- Fund for Shanxi 1331 Project Key Innovative Research Team
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Oxygenated Polycyclic aromatic hydrocarbons (Oxy-PAHs) are widely distributed in the atmosphere, water, soil and sediments. Oxy-PAHs have been proved more carcinogenic than their parent PAHs, while there still lack of studies about the toxicological mechanism of Oxy-PAHs in epigenetic regulation. Our study revealed that exposure to Oxy-PAHs induced the invasion and migration of lung epithelial cells by the activation of epithelial-to-mesenchymal transition (EMT), including the up-regulation of Vimentin and alpha-smooth muscle actin (alpha-SMA) and the down-regulation of E-cadherin (E-cad). The reactive oxygen species (ROS) promoted histone acetylation mediated-Snail regulating the expression of E-cad after Oxy-PAHs treatment. Meanwhile, DNA methylation was also involved in epigenetic regulation of EMT. These results demonstrated a potential mechanism about Oxy-PAHs facilitate lung carcinogenesis by epigenetic regulation and suggested new ways for the treatment, improvement, and prevention of lung cancer caused by Oxy-PAHs environmental exposure. (C) 2019 Elsevier Ltd. All rights reserved.
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