Advance on toxicity of metal nickel nanoparticles

As a kind of conventional metal nanomaterial, nickel nanoparticles (Ni NPs) have broad application prospects in the fields of magnetism, energy technology and biomedicine and have quickly attracted great interest. The potential negative effects of Ni NPs have also attracted wide attention from some researchers. Studies have shown that Ni NPs cause a variety of toxic effects on cells, animals and humans and have toxic effects of multiple systems such as respiratory system, cardiovascular system and reproductive system. Ni NPs can lead to oxidative stress, apoptosis, DNA damage and inflammation and induce the increase of intracellular reactive oxygen species. The toxicity of Ni NPs is also found to be related to the mitogen-activated protein kinase pathway and the hypoxia inducible factor-1 alpha pathway. Therefore, the toxicity and mechanism of Ni NPs are reviewed in this paper, and the future researches in this field are also proposed.