Journal
ENVIRONMENT INTERNATIONAL
Volume 136, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2019.105422
Keywords
Cholestasis; Food additives; Dietary supplements; Herbal supplements; Parenteral nutrition
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Funding
- European Marie-Curie Sklodowska Action program (MSCA) [833095]
- Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University Baltimore-USA
- Fund for Scientific ResearchFlanders (FWO-Vlaanderen)
- University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel)
- Marie Curie Actions (MSCA) [833095] Funding Source: Marie Curie Actions (MSCA)
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Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.
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