Journal
BRAIN RESEARCH BULLETIN
Volume 120, Issue -, Pages 83-89Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2015.10.010
Keywords
Nucleus incertus; Hippocampus; Medial prefrontal cortex; Stress; c-Fos; Plasticity
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Funding
- Biomedical Research Council of Singapore [BMRC 10/1/21/19/645]
- National Medical Research Council of Singapore [NMRC/1287/2011]
- NMRC NUHS Centre Grant-Neuroscience Phenotyping Core [NMRC/CG/013/2013]
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The nucleus incertus (NI) is a small cluster of brainstem neurons presumed to play a role in stress responses. We show that swim stress (normal water: 30 min and cold water: 20 min) and elevation stress robustly induced c-Fos expression in the NI and significantly suppressed long-term potentiation (LTP) in the hippocampo-medial prefrontal cortical (HP-mPFC) pathway. To examine whether activation of CRF1 receptors in the NI plays a role in the suppression of HP-mPFC LTP, antalarmin, a specific CRF1 receptor antagonist, was infused directly into the NI either before presentation of (1) elevation stress or (2) high frequency stimulation. As predicted, the intra-NI infusion of antalarmin reversed the elevation stress-induced suppression of LTP in the HP-mPFC pathway. This report suggests that the CRF1 receptor in the NI contributes to stress-related impairment in plasticity of the HP-mPFC pathway. The findings suggest that the NI-HP-mPFC is a stress responsive circuit in the rodent brain. (C) 2015 The Authors. Published by Elsevier Inc.
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