Journal
BRAIN RESEARCH BULLETIN
Volume 125, Issue -, Pages 1-18Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2016.03.017
Keywords
Astrocyte; Heterogeneity; Function; Neurological disease; CNS injury
Categories
Funding
- National Natural Science Foundation [81271352, 31171124]
- Shanghai Pujiang Program [15PJ1410500]
- Science and Technology Commission of Shanghai Municipality [15JC1400202]
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Astrocytes, the predominant cell type that are broadly distributed in the brain and spinal cord, play key roles in maintaining homeostasis of the central nerve system (CNS) in physiological and pathological conditions. Increasing evidence indicates that astrocytes are a complex colony with heterogeneity on morphology, gene expression, function and many other aspects depending on their spatio-temporal distribution and activation level. In pathological conditions, astrocytes differentially respond to all kinds of insults, including injury and disease, and participate in the neuropathological process. Based on current studies, we here give an overview of the roles of heterogeneous astrocytes in CNS, especially in neuropathologies, which focuses on biological and functional diversity of astrocytes. We propose that a precise understanding of the heterogeneous astrocytes is critical to unlocking the secrets about pathogenesis and treatment of the mazy CNS. (C) 2016 Elsevier Inc. All rights reserved.
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