Journal
EMBO MOLECULAR MEDICINE
Volume 12, Issue 3, Pages -Publisher
WILEY
DOI: 10.15252/emmm.201911505
Keywords
axon regeneration; clinical trials; combination treatments; reproducibility; spinal cord injury
Categories
Funding
- IRP
- WfL
- DFG
- ERANET AXON REPAIR
- ERANET RATER SCI
- Roger de Spoelberch Prize
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The recent years saw the advent of promising preclinical strategies that combat the devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials. However, individually, these treatments produce only modest levels of recovery in animal models of SCI that could hamper their implementation into therapeutic strategies in spinal cord injured humans. Combinational strategies have demonstrated greater beneficial outcomes than their individual components alone by addressing multiple aspects of SCI pathology. Clinical trial designs in the future will eventually also need to align with this notion. The scenario will become increasingly complex as this happens and conversations between basic researchers and clinicians are required to ensure accurate study designs and functional readouts.
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