Journal
ELECTROPHORESIS
Volume 41, Issue 16-17, Pages 1425-1432Publisher
WILEY
DOI: 10.1002/elps.201900420
Keywords
Biomedical measurement; Electrical impedance spectroscopy; Equivalent circuit fitting; Least squares method
Funding
- National Natural Science Foundation of China [51706098]
- Natural Science Foundation of Zhejiang Province [LY19E050010, LY18E050012]
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The electrical characteristics of biological tissue is evaluated by establishing an electrical equivalent circuit with electrical impedance spectroscopy. The least squares method is used to realize electrical equivalent circuit fitting by using the developed portable electrical impedance spectroscopy system. The EIS system is used to obtain the impedance spectrum data of the measured biological tissue. In the experiment, the impedance spectrum data of eggs under different heating time were measured, and the established equivalent circuit model of eggs was fitted by nonlinear least squares fitting algorithm. Moreover, the electrical characteristics of the biological tissue are also revealed by numerical simulation with HANAI model. The experimental and simulation results show that the extracted equivalent electrical parameters can clearly characterize the variation of the internal change of components of biological tissues.
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