Journal
ELECTROANALYSIS
Volume 32, Issue 5, Pages 1017-1024Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201900580
Keywords
Piroxicam; Amlodipine; Pt doped NiO nanoparticles; Modified glassy carbon electrode
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Funding
- research council of Arak University [98.662]
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In this paper, a high-sensitivity electrochemical sensor based on platinum (Pt) doped nickel oxide (NiO) nanoparticles and multi-walled carbon nanotubes (MWCNTs) modified glassy carbon electrode (Pt-NiO/MWCNTs/GCE) has been developed to determine piroxicam (PIR) and amlodipine (AML) simultaneously. The electrochemical behavior of PIR and AML at the proposed sensor has been investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) methods. Pt doped NiO nanoparticles were synthesized by the sol-gel procedure and were investigated using X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and field emission scanning electron microscopy (FESEM) techniques. DPV responses of PIR and AML increased linearly with their concentration in wide linear dynamic ranges of 0.6-320.0 mu M and 1.0-250.0 mu M, respectively. The limits of detection were 0.061 mu M for PIR and 0.092 mu M for AML. The excellent analytical figure of merits of the proposed modified electrode leads to application of it promising electrochemical sensor to determine PIR and AML in human serum and urine with satisfactory results.
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