Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction

Background: Elevated cerebral fractional tissue oxygen extraction (cFTOE) is an adaptation to anemia of prematurity (AOP). cFFOE >= 0.4 is associated with brain injury in infants <= 30 weeks. This longitudinal study sought to investigate the utility of cFTOE in the evaluation of AOP. Methods: Infants <= 30 weeks estimated gestational age (EGA) underwent weekly hemoglobin, cerebral saturation, and pulse oximetry recordings from the second through 36 weeks post-menstrual age (PMA). Recordings were excluded if they were under 1 h or if hemoglobin was not measured within 7 days of recording. Mean cFTOE was calculated for each recording. Statistical analysis used linear mixed-effects modeling and receiver operating characteristic analysis. Results: 144 recordings from 39 infants (mean EGA 27.6 +/- 2.2 weeks,BW 1139 +/- 286 g) were included of whom 39% (15/39) were transfused. The mean recording length was 2.8 +/- 1.3 h. There was a significant negative correlation between hemoglobin and cFTOE (R = - 0.423, p <= .001). In a multivariate model, adjusting for EGA, PMA, and patent ductus arteriosus treatment the AUC was 0.821. A critical increase in cFTOE occurred at a hemoglobin level of 9.6 g/dL. Conclusions: AOP is associated with a critical increase in cFTOE that occurs at a significantly higher hemoglobin level than standard clinical thresholds for transfusion.