Relationship Between Tongue Pressure and Pharyngeal Function Assessed Using High-Resolution Manometry in Older Dysphagia Patients with Sarcopenia: A Pilot Study

Tongue pressure is often used to evaluate swallowing muscle strength in dysphagia patients with sarcopenia. However, the amount of tongue pressure that reflects pharyngeal swallowing function is unclear. The aims of this descriptive study were (1) to assess the association between tongue pressure and swallowing function using high-resolution manometry (HRM), (2) to evaluate whether manometric parameters were related to maximum tongue pressure (MTP) and other sarcopenia-related factors, and (3) to evaluate the manometric characteristics of pharyngeal swallowing in sarcopenic dysphagia. Sixteen patients with dysphagia (13 men; mean age 85.0 +/- 6.6) who were diagnosed with sarcopenia and sixteen healthy subjects (10 men; mean age 33.6 +/- 7.2) were included. Evaluation of HRM parameters including velopharyngeal contractile integral (VPCI), mesohypopharyngeal contractile integral (MHPCI), upper esophageal sphincter (UES) relaxation duration, and UES nadir pressure was performed. HRM parameters of patients were compared with MTP, sarcopenia factors, and manometric parameters of healthy subjects. The VPCI showed no statistically significant differences between patient and healthy groups. In the patient group, the MHPCI was significantly lower (126.1 +/- 76.6 vs 193.2 +/- 34.1 mmHg cm s;p = 0.003), UES nadir pressure was significantly higher (10.5 +/- 27.5 vs - 11.2 +/- 6.7 mmHg;p < 0.001), and UES relaxation duration (318.0 +/- 152.4 vs 520.6 +/- 60.0 ms;p = 0.007) was significantly shorter than those in the healthy group. HRM parameters were not significantly correlated with MTP and sarcopenia factors. Older dysphagia patients with sarcopenia had weaker pharyngeal contractility and UES dysfunction. Manometric evaluation of pharyngeal function may not be significantly associated with MTP and sarcopenia-related factors. Further study is needed to clinically apply tongue pressure for evaluating sarcopenic dysphagia.

Automated summary

This study aimed to assess the relationship between tongue pressure and swallowing function, and found that dysphagia patients with sarcopenia have weaker pharyngeal contractility and UES dysfunction. However, there was no significant correlation between HRM parameters and tongue pressure as well as sarcopenia-related factors. Further research is needed to clinically apply tongue pressure in evaluating sarcopenic dysphagia.