Journal
DRUG DISCOVERY TODAY
Volume 25, Issue 5, Pages 862-878Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2020.01.008
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Funding
- Science and Engineering Research Board (Statutory Body Established through an Act of Parliament: SERB Act 2008), Department of Science and Technology, Government of India [ECR/2016/001964, PDF/2016/003329]
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India
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Diabetes and related complications are becoming a global encumbrance. Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD). The available therapeutic modalities related to DN do not treat DN at the molecular level, proposing further amendments in the management of DN based on the pathogenesis of DN. This manuscript discusses the concept and applications of nanomedicine for the treatment of DN that can improve renal targeting, retention and localization. This review also highlights the current issues related to targeting DN, challenges and allied opportunities toward the development of next-generation drugs and treatments for the management of DN.
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