Journal
DNA REPAIR
Volume 87, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2020.102804
Keywords
AlkB; ALKBH; ALKBH3; RAD51; RAD51C; DNA repair; ssDNA; Abasic site; AGT; MGMT; NEIL3; UNG2
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Funding
- Science and Engineering Research Board (SERB), Govt. of India [EMR/2016/005135/BBM]
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Cellular processes, such as DNA replication, recombination and transcription, require DNA strands separation and single-stranded DNA is formation. The single-stranded DNA is promptly wrapped by human single-stranded DNA binding proteins, replication protein A (RPA) complex. RPA binding not only prevent nuclease degradation and annealing, but it also coordinates cell-cycle checkpoint activation and DNA repair. However, RPA binding offers little protection against the chemical modification of DNA bases. This review focuses on the type of DNA base damage that occurs in single-stranded DNA and how the damage is rectified in human cells. The discovery of DNA repair proteins, such as ALKBH3, AGT, UNG2, NEIL3, being able to repair the damaged base in the single-stranded DNA, renewed the interest to study single-stranded DNA repair. These mechanistically different proteins work independently from each other with the overarching goal of increasing fidelity of recombination and promoting error-free replication.
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