Journal
BRAIN RESEARCH
Volume 1648, Issue -, Pages 603-616Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2016.02.033
Keywords
ER stress; Proteasome; Parkinson's disease; Ischemia; Hormesis; Autophagy; Wolfram syndrome; Glioblastoma
Categories
Funding
- ANR/FCT [IRE1-PD ANR-13-ISV4-0003-01]
- Fondation de France [2012-00034435]
- Labex MemoLife [ANR-10-LABX-54 MEMOLIFE]
- Idex PSL Research University
- ADR from ARC2 region Rhone Alpes, France
- Societe Francophone du Diabete (SFD/MSD)
- Societe Francaise d'Hepatologie (AFEF/Aptalis)
- La Ligue Contre le Cancer
- Fundacao para a Ciencia e a Tecnologia [FCT-ANR/NEU-NMC/0006/2013]
- NIH [DK067493, DK020579, UL1 TR000448, R01 EY020866, R37 DK042394, R01 DK088227, R01 DK103183]
- JDRF [17-2013-512]
- ADA [1-12-CT-61]
- Ellie White Foundation for Rare Genetic Disorders
- Team Ian
- Team Alejandro
- Snow Foundation
- Dr. Miriam and Sheldon Adelson Medical Research Foundation (AMRF)
- Israel Science Foundation (ISF)
- Israel Centers of Research Excellence Program (I-CORE) [1775/12]
- Professorship of the Israel Cancer Research Fund (ICRF USA)
- Wellcome Trust [096409/Z/11/Z]
- CDMRP Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Idea Award [AL150111]
- Wellcome Trust [096409/Z/11/Z] Funding Source: Wellcome Trust
- Fundação para a Ciência e a Tecnologia [FCT-ANR/NEU-NMC/0006/2013] Funding Source: FCT
Ask authors/readers for more resources
In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the unfolded protein response, the ubiquitin proteasome system and autophagy. Interestingly, several recent studies have shown that these adaptive responses can be stimulated by preconditioning treatments, which confer resistance to a subsequent toxic challenge - the phenomenon known as hormesis. In this review we discuss the impact of adaptive stress responses stimulated in diverse human neuropathologies including Parkinson's disease, Wolfram syndrome, brain ischemia, and brain cancer. Further, we examine how these responses and the molecular pathways they recruit might be exploited for therapeutic gain. This article is part of a Special Issue entitled SI:ER stress. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available