Journal
BRAIN PATHOLOGY
Volume 26, Issue 3, Pages 404-409Publisher
WILEY
DOI: 10.1111/bpa.12371
Keywords
synuclein; Parkinson's disease; inflammation; microglia; eurodegeneration
Categories
Funding
- Seoul National University Hospital
- National Research Foundation (NRF) grant - Korean Government (MEST) [2015R1A2A10052540, 2015R1A2A1505366]
- Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HI14C0093]
- Korea Health Promotion Institute [HI14C0093020016] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all, inflammation in the nervous system has been implicated in many neurodegenerative diseases. Still, the roles of neuroinflammation in disease mechanisms and the triggers of inflammatory responses in disease-inflicted brain tissues seem to remain unclear. This review will examine previous studies that had been done from genetic, pathological and epidemiological perspectives. These studies assess the involvement of neuroinflammation in synucleinopathies, a group of neurodegenerative diseases that are characterized by deposition of alpha-synuclein aggregates such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. The review will also discuss the role of alpha-synuclein aggregates in triggering inflammatory responses from glial cells. It is expected that a precise assessment of the roles and mechanisms of neuroinflammation in neurodegenerative diseases will pave the way for the development of disease-modifying drugs.
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