Journal
BRAIN PATHOLOGY
Volume 26, Issue 5, Pages 648-663Publisher
WILEY
DOI: 10.1111/bpa.12403
Keywords
Alzheimer's disease; exercise; mitochondria
Categories
Funding
- Portuguese Foundation for Science and Technology (FCT) [POCI-01-0145-FEDER-016690, PTDC/DTP-DES/7087/2014]
- Research Center in Physical Activity, Health and Leisure (CIAFEL) [UID/DTP/00617/2013]
- FCT grants [SFRH/BD/93281/2013, SFRH/BPD/108322/2015]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/93281/2013, SFRH/BPD/108322/2015, PTDC/DTP-DES/7087/2014] Funding Source: FCT
Ask authors/readers for more resources
Exercise is one of the most effective strategies to maintain a healthy body and mind, with particular beneficial effects of exercise on promoting brain plasticity, increasing cognition and reducing the risk of cognitive decline and dementia in later life. Moreover, the beneficial effects resulting from increased physical activity occur at different levels of cellular organization, mitochondria being preferential target organelles. The relevance of this review article relies on the need to integrate the current knowledge of proposed mechanisms, focus mitochondria, to explain the protective effects of exercise that might underlie neuroplasticity and seeks to synthesize these data in the context of exploring exercise as a feasible intervention to delay cognitive impairment associated with neurodegenerative conditions, particularly Alzheimer disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available