Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 62, Issue 1, Pages 35-48Publisher
WILEY
DOI: 10.1111/dgd.12643
Keywords
EGF repeats; human diseases; Notch signaling; O-glycosylation
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Funding
- Japan Society for the Promotion of Science [JP17H06743, JP19H03176]
- Daiichi Sankyo Foundation of Life Science
- Takeda Science Foundation
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Notch signaling is an evolutionarily conserved signaling pathway and is essential for cell-fate specification in metazoans. Dysregulation of Notch signaling results in various human diseases, including cardiovascular defects and cancer. In 2000, Fringe, a known regulator of Notch signaling, was discovered as a Notch-modifying glycosyltransferase. Since then, glycosylation-a post-translational modification involving literal sugars-on the Notch extracellular domain has been noted as a critical mechanism for the regulation of Notch signaling. Additionally, the presence of diverse O-glycans decorating Notch receptors has been revealed in the extracellular domain epidermal growth factor-like (EGF) repeats. Here, we concisely summarize the recent studies in the human diseases associated with aberrant Notch glycosylation.
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