Journal
DEVELOPMENT
Volume 147, Issue 1, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.181636
Keywords
Cancer; Epimorphic regeneration; Immune system; Solid tumor; Stroma; Wound healing
Categories
Funding
- National Institutes of Health [1DP2HD087953-01]
- Richard and Susan Smith Family Foundation (Odyssey Award)
Ask authors/readers for more resources
Striking similarities between wound healing, epimorphic regeneration and the progression of solid tumors have been uncovered by recent studies. In this Review, we discuss systemic effects of tumorigenesis that are now being appreciated in epimorphic regeneration, including genetic, cellular and metabolic heterogeneity, changes in circulating factors, and the complex roles of immune cells and immune modulation at systemic and local levels. We suggest that certain mechanisms enabling regeneration may be co-opted by cancer to promote growth at primary and metastatic sites. Finally, we advocate that working with a unified approach could complement research in both fields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available