Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 52, Issue -, Pages 76-87Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2020.02.001
Keywords
Adipokines; Myokines; Cytokines; Obesity; Breast cancer; Physical activity
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Funding
- PhD fellowship (Delphine Le Guennec) from le Comite national de La Ligue contre le cancer
- local council (Allier)
- local council (Cantal)
- local council (Haute-Vienne)
- local council (Haute-Loire)
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Regular physical activity is known to protect against the development of breast cancer and mediate direct anti-inflammatory effects on adipose tissue. While direct relationships between muscle activity, adipose tissue and breast tissue have been highlighted in recent years, few studies have focused on the effects of obesity and physical activity during the development of breast cancer, particularly at the level of cell signaling. Skeletal muscle and adipose tissue modulate the cell metabolism by secreting myokines and adipokines. These secreted cytokines belong to a crosstalk network via cell signaling pathway modulation. The understanding of the tissue crosstalk is fundamental to the management of physical activity in the care of obese breast cancer patients. Therefore, this review focuses on the effects of obesity and physical activity during the development of breast cancer, particularly at the level of cell signaling. We focuse on the main mediators, secreted by both adipose and muscle tissue, which are implicated in breast cancer development. We presente the variation of these mediators in the physiopathological context of their secreted tissue. Then, we open the discussion on the crosstalk of these tissues in breast carcinogenesis.
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