Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 20, Issue 10, Pages 815-834Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026620666200303123102
Keywords
EGFR; HER-1; ERBB-1; Tyrosine kinase; EGF; TGF-alpha; mAbs; Inhibitors; cancer
Categories
Funding
- Deanship of Scientific Research and Graduate Studies at Al-Zaytoonah University of Jordan
Ask authors/readers for more resources
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available