Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 25, Issue 46, Pages 4848-4860Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612825666191216150948
Keywords
Carbon quantum dots; fluorescence; bacterial detection; antimicrobial activity; reactive oxygen species; photoactivation
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Funding
- Ministry of Science and Technology of Taiwan [MOST107-2221-E-182-058-MY3, 107-2113-M-019-004-MY3, 108-2638-M-002-001-MY2]
- Center of Excellence for the Oceans, National Taiwan Ocean University from The Featured Areas Research Center Program within Ministry of Education (MOE) in Taiwan
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The prevention and treatment of various infections caused by microbes through antibiotics are becoming less effective due to antimicrobial resistance. Researches are focused on antimicrobial nanomaterials to inhibit bacterial growth and destroy the cells, to replace conventional antibiotics. Recently, carbon dots (C-Dots) become attractive candidates for a wide range of applications, including the detection and treatment of pathogens. In addition to low toxicity, ease of synthesis and ftmctionalization, and high biocompatibility, C-Dots show excellent optical properties such as multi-emission, high brightness, and photostability. C-Dots have shown great potential in various fields, such as biosensing, nanomedicine, photo-catalysis, and bioimaging. This review focuses on the origin and synthesis of various C-Dots with special emphasis on bacterial detection, the antibacterial effect of C-Dots, and their mechanism.
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