Journal
CURRENT ORGANIC CHEMISTRY
Volume 23, Issue 21, Pages 2295-2318Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272823666191016165532
Keywords
Organic synthesis; solvent-free technique; solid-state reactions; green chemistry; mechanochemistry; microwave irradiation; ultrasound irradiation
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Most of the synthetic chemical transformation reactions involve the use of different organic solvents. Unfortunately, some of these toxic solvents are used in chemical laboratory, industry and have been considered a very serious problem for the health, safety of workers and environmental damage through pollution. The purpose of green chemistry is to provide a path that reduces or eliminates the use of such hazardous toxic solvents. Therefore, the key factor of the green synthetic approach is to utilize renewable materials, nontoxic chemical and to perform the reactions under solvent-free conditions. In this review, we have discussed most recent literature survey on applications of solvent-free techniques in organic synthesis which would offer a new opportunity to a researcher to overcome the problem of using environmental harmful solvents.
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