Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 59, Issue -, Pages 47-53Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.02.004
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Funding
- NIH [CA74305]
- Kwanjeong Educational Foundation
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Akt1-3 (Akt) are a subset of the AGC protein Ser/Thr kinase family and play important roles in cell growth, metabolic regulation, cancer, and other diseases. We describe some of the roles of Akt in cell signaling and the biochemical and structural mechanisms of the regulation of Akt catalysis by the phospholipid PIP3 and by phosphorylation. Recent findings highlight a diverse set of strategies to control Akt catalytic activity to ensure its normal biological functions.
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