Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 53, Issue -, Pages 26-34Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2020.01.017
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Funding
- National Institute of Allergy and Infectious Diseases [5R21AI135641]
- National Office of Research Infrastructure Programs at the NIH [5R24OD010998]
- National Science Foundation [DEB] [1911994]
- Morris Animal Foundation [D18ZO-405]
- BBSRC [BB/T011416/1] Funding Source: UKRI
- Division Of Environmental Biology
- Direct For Biological Sciences [1911994] Funding Source: National Science Foundation
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Intestinal helminth parasites present major challenges to the welfare of humans and threaten the global food supply. While the discovery of anthelminthic drugs empowered our ability to offset these harms to society, the alarming rise of anthelminthic drug resistance mitigates contemporary efforts to treat and control intestinal helminthic infections. Fortunately, emerging research points to potential opportunities to combat anthelminthic drug resistance by harnessing the gut microbiome as a resource for discovering novel therapeutics and informing responsible drug administration. In this review, we highlight research that demonstrates this potential and provide rationale to support increased investment in efforts to uncover and translationally utilize knowledge about how the gut microbiome mediates intestinal helminthic infection and its outcomes.
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