Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 52, Issue -, Pages 90-99Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2019.05.007
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/R008485/1]
- European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC [614562]
- BBSRC [BB/R008485/1] Funding Source: UKRI
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Extracellular vesicles play a significant role in many aspects of cellular life including cell-to-cell communication, pathogenesis and cancer progression. However very little is known about their role in fungi and we are just at the beginning of understanding their influence on fungal pathophysiology and host pathogen interactions. Recent findings have revealed a role for fungal vesicles in triggering anti-microbial activities as well as in modulating virulence strategies, suggesting potential new avenues for antifungal therapies. In this review, we summarize our current understanding of fungal extracellular vesicles, including their biogenesis, secretion and size variation, and discuss how they may influence the human immune response and some key questions that remain unanswered.
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