Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 62, Issue -, Pages 79-90Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.12.002
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Funding
- Fonds Wetenschappelijk Onderzoek Vlaanderen [G0C8517N]
- CSL Behring Chair in Primary Immunodeficiencies
- KID-FONDS charity of KU Leuven
- Jeffrey Modell Foundation
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The germline encoded innate immunity governs eukaryotic host defense through both hematopoietic and non-hematopoietic cells, whereas adaptive immunity actions mainly via T cells and B cells characterized by their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity typically underlie infectious diseases. Disturbed innate immunity can additionally result in auto-inflammation. Here, we review inborn errors of innate immunity that have been recently discovered as well as new insights into previously described inborn errors of innate immunity.
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