Journal
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
Volume 44, Issue -, Pages 130-142Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.cocis.2019.09.007
Keywords
Enzyme encapsulation; Enzyme activity; Pore size; Polar lipid liquid crystals; Cubic phase; Mesoporous silica
Categories
Funding
- FIR
- RAS
- Fondazione di Sardegna [CUP F72F16003070002]
- MIUR (FFABR 2017), Italy
- NanoLund, Lund University, Sweden
- European Commision [PITN-GA-2013-606713]
- European Union
- Swedish Research Council [2016-05390, 2017-06716, 2018-05013]
- Swedish Foundation for Strategic Research (Swedish Research School for Neutrons (SwedNess), Sweden
- [H2020-FETOPEN-1-2016-2017-801367]
- Vinnova [2018-05013] Funding Source: Vinnova
- Swedish Research Council [2018-05013, 2017-06716, 2016-05390] Funding Source: Swedish Research Council
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Enzymes have come into use for many new applications outside their natural biological environment, taking advantage of their high efficiency and selectivity as biocatalysts. Such new application often requires encapsulation to preserve the structure and activity of the enzyme, but also to regulate and control the activity. Here, we will discuss two types of encapsulation, soft matrices consisting of polar lipid liquid crystals and hard ordered mesoporous silica matrices. For both types of matrices, the challenge is to control the pore size of the matrices and the interaction with the matrix interface. Here, the polar lipid liquid crystals offer larger flexibility than silica, but on the other hand, it is considerably more sensitive to the environment.
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