Chemoproteomic profiling of protein-metabolite interactions

Small molecule metabolites play important roles in regulating protein functions, which are acted through either covalent nonenzymatic post-translational modifications or non-covalent binding interactions. Chemical proteomic strategies can help delineate global landscapes of cellular protein-metabolite interactions and provide molecular insights about their mechanisms of action. In this review, we summarized the recent progress in developments and applications of chemoproteomic strategies to profile protein-metabolite interactions.