Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 62, Issue -, Pages 9-16Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.07.013
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Funding
- ERC [340784]
- LA Fondation ARC pour la recherche sur le cancer [PGA1 RF20180206793]
- Agence Nationale de la Recherche (ANR) [Labex DEEP 11-LBX-0044, ANR-10-IDEX-0001-02 PSL]
- Marie SklodowskaCurie Actions Innovative Training Network [675407]
- Fondation pour la Recherche Medicale (FRM) [SPF20170938661]
- Marie Curie Actions (MSCA) [675407] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [340784] Funding Source: European Research Council (ERC)
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Mitotic spindle orientation has been linked to asymmetric cell divisions, tissue morphogenesis and homeostasis. The canonical pathway to orient the mitotic spindle is composed of the cortical recruitment factor NuMA and the molecular motor dynein, which exerts pulling forces on astral microtubules to orient the spindle. Recent work has defined a novel role for NuMA as a direct contributor to force generation. In addition, the exploration of geometrical and physical cues combined with the study of classical polarity pathways has led to deeper insights into the upstream regulation of spindle orientation. Here, we focus on how cell shape, junctions and mechanical tension act to orient spindle pulling forces in epithelia, and discuss different roles for spindle orientation in epithelia.
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