Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 60, Issue -, Pages 179-187Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.05.008
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Funding
- Molecular Principles of Synthetic Biology - Deutsche Forschungsgemeinschaft (DFG) [GRK2062]
- MaxSynBio consortium - Federal Ministry of Education and Research of Germany
- MaxSynBio consortium - Max Planck Society
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Bottom-up reconstituting well-characterized functional molecular entities, parts and modules towards a synthetic cell will give new insights into the mechanisms and origin of life. However, a remaining central challenge is how to organize cellular processes spatiotemporally from their component parts in vitro. Here, we review cutting edge tools and technologies that can facilitate such a bottom-up reconstitution towards a synthetic cell in space and time, particularly with regard to the following aspects: (1) reliable model membrane-environment and microenvironment; (2) dynamic genetic regulation and self-sustaining transcription and translation machinery; (3) spatially organized cytoskeleton that supports the biological architecture and cellular self-reproduction in 3D.
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