Journal
CURRENT MEDICINAL CHEMISTRY
Volume 28, Issue 2, Pages 213-237Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867327666200210144847
Keywords
Cannabis sativa; cannabidiol; extractive methods; chromatography; synthesis of CBD; in silico studies
Funding
- University of Brescia, Brescia, Italy
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This review comprehensively addresses extractive and analytical approaches for CBD, highlighting recent cutting-edge technologies and synthetic methods. In addition, computational studies on molecular interactions of CBD towards various targets are discussed to provide a comprehensive overview of CBD's potential and therapeutic profile.
Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the phytocomplex of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile.
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