Journal
CURRENT BIOLOGY
Volume 30, Issue 3, Pages 396-+Publisher
CELL PRESS
DOI: 10.1016/j.cub.2019.11.065
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Funding
- MEXT KAKENHI [JP16H04655, JP18H05069, 19H04933, 17K19450, 15K07147, 18K06332]
- Naito Foundation
- Inamori Foundation Research Grant, Japan
- Grants-in-Aid for Scientific Research [19H04933, 18K06332, 15K07147, 17K19450] Funding Source: KAKEN
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In the early phase of courtship, female fruit flies exhibit an acute rejection response to avoid unfavorable mating. This pre-mating rejection response is evolutionarily paralleled across species, but the molecular and neuronal basis of that behavior is unclear. Here, we show that a putative incoherent feedforward circuit comprising ellipsoid body neurons, cholinergic R4d, and its repressor GABAergic R2/R4m neurons regulates the pre-mating rejection response in the virgin female Drosophila melanogaster. Both R4d and R2/R4m are positively regulated, via specific dopamine receptors, by a subset of neurons in the dopaminergic PPM3 cluster. Genetic deprivation of GABAergic signal via GABA(A) receptor RNA interference in this circuit induces a massive rejection response, whereas activation of GABAergic R2/R4m or suppression of cholinergic R4d increases receptivity. Moreover, glutamatergic signaling via N-methyl-D-aspartate receptors induces NO-mediated retrograde regulation potentially from R4d to R2/R4m, likely providing flexible control of the behavioral switching from rejection to acceptance. Our study elucidates the molecular and neural mechanisms regulating the behavioral selection process of the pre-mating female.
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