Journal
CURRENT APPLIED PHYSICS
Volume 20, Issue 1, Pages 155-160Publisher
ELSEVIER
DOI: 10.1016/j.cap.2019.10.020
Keywords
Cardiomyocyte; Piezoelectric sensor; Cantilever; Contraction force
Funding
- Academy of Finland [310347, 310527]
- Academy of Finland (AKA) [310527, 310347, 310527, 310347] Funding Source: Academy of Finland (AKA)
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A proof-of-concept method for measuring cardiac tissue contraction force using an in-house-developed piezoelectric cantilever sensor system is demonstrated. Contracting forces of 7.2-16.6 mu N (n = 5) were measured from a human cardiac tissue construct. Beating cardiac tissue constructs were monitored in-situ under a microscope during the contraction force measurements. Development of the measurement method allows very low forces such as the ones that appear in biological small scale systems to be determined.
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