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Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation
Anthony B. Mak et al.
JOURNAL OF MOLECULAR BIOLOGY (2014)
Isomerization of Δ5-Androstene-3,17-dione into Δ4-Androstene-3, 17-dione Catalyzed by Human Glutathione Transferase A3-3: A Computational Study Identifies a Dual Role for Glutathione
Daniel F. A. R. Dourado et al.
JOURNAL OF PHYSICAL CHEMISTRY A (2014)
Development of Molecular Probe Targeting on Glutathion Transferase
Mika Ito et al.
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN (2014)
Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
Linn Fagerberg et al.
MOLECULAR & CELLULAR PROTEOMICS (2014)
Preliminary detection of the anti-tumour activity of indoline-2,3-dione derivative DH-12a targeting aminopeptidase N
De-Xuan Cui et al.
MOLECULAR MEDICINE REPORTS (2014)
Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA
Michelle T. Paulsen et al.
METHODS (2014)
Gamma-Glutamyltransferase Fractions in Human Plasma and Bile: Characteristic and Biogenesis
Irene Fornaciari et al.
PLOS ONE (2014)
Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-Expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute Myeloid Leukemia
Yiming Tian et al.
PLOS ONE (2014)
The Role of N-Acetyltransferase 8 in Mesenchymal Stem Cell-Based Therapy for Liver Ischemia/Reperfusion Injury in Rats
Jinqiu Fu et al.
PLOS ONE (2014)
8-Methoxypsoralen is a competitive inhibitor of glutathione S-transferase P1-1
Diego Madureira de Oliveira et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery
Gordon Saxty et al.
MEDCHEMCOMM (2014)
Cysteine-reactive chemical probes based on a modular 4-aminopiperidine scaffold
Shatise M. Couvertier et al.
MEDCHEMCOMM (2014)
The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex
A. De Luca et al.
CELL DEATH & DISEASE (2014)
Genetic Determinants Influencing Human Serum Metabolome among African Americans
Bing Yu et al.
PLOS GENETICS (2014)
Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans
Linda Bjorkhem-Bergman et al.
FEBS OPEN BIO (2014)
Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma
Marina Tuzova et al.
FRONTIERS IN PHARMACOLOGY (2014)
Glutathione S-conjugates as prodrugs to target drug-resistant tumors
Emma E. Ramsay et al.
FRONTIERS IN PHARMACOLOGY (2014)
Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a)
Christopher D. Boone et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2014)
Transport of Amino Acids in the Kidney
Victoria Makrides et al.
COMPREHENSIVE PHYSIOLOGY (2014)
Mice Lacking Three Loci Encoding 14 Glutathione Transferase Genes: A Novel Tool for Assigning Function to the GSTP, GSTM, and GSTT Familiess
Zhidan Xiang et al.
DRUG METABOLISM AND DISPOSITION (2014)
The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems
Nicolas Garnier et al.
MOLECULAR PHARMACOLOGY (2014)
Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease
Li Wang et al.
AAPS JOURNAL (2013)
MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping
Fausta Di Cianni et al.
AGE (2013)
Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
Aya Shibata et al.
ANALYST (2013)
Phenotype versus Genotype Methods for Copy Number Variant Analysis of Glutathione S-Transferases M1
Sara Piacentini et al.
ANNALS OF HUMAN GENETICS (2013)
Human GGT2 Does Not Autocleave into a Functional Enzyme: A Cautionary Tale for Interpretation of Microarray Data on Redox Signaling
Matthew B. West et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Metabolism of arsenic and its toxicological relevance
Takayuki Watanabe et al.
ARCHIVES OF TOXICOLOGY (2013)
Inhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors
Stephanie Wickham et al.
BIOCHEMICAL JOURNAL (2013)
The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo
Sara Strese et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Catalytic Characterization of Human Microsomal Glutathione S-Transferase 2: Identification of Rate-Limiting Steps
Shabbir Ahmad et al.
BIOCHEMISTRY (2013)
Glutathione and glutathione analogues; Therapeutic potentials
Jian Hui Wu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Glutathione transferases, regulators of cellular metabolism and physiology
Philip G. Board et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
Marcel Deponte
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Design and Synthesis of Small-Molecule Fluorescent Photoprobes Targeted to Aminopeptdase N (APN/CD13) for Optical Imaging of Angiogenesis
Anke Hahnenkamp et al.
BIOCONJUGATE CHEMISTRY (2013)
Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN)
Kang Jin et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy
Celine Schmitt et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent
Li Su et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN)
Chunhua Ma et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer
C. Grimm et al.
BRITISH JOURNAL OF CANCER (2013)
A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours
Laura Horsley et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)
Reduction of Dimethylarsinic Acid to the Highly Toxic Dimethylarsinous Acid by Rats and Rat Liver Cytosol
Balazs Nemeti et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2013)
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1
Yaman Musdal et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Donor substrate specificity of bovine kidney gamma-glutamyltransferase
Anita A. Agblor et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells
Bo Wang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Overexpression of aminoacylase 1 is associated with colorectal cancer progression
Hongjun Shi et al.
HUMAN PATHOLOGY (2013)
Novel Insights into Eukaryotic γ-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme
Matthew B. West et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A Role for Glutathione Transferase Omega 1 (GSTO1-1) in the Glutathionylation Cycle
Deepthi Menon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE
Alessio Bocedi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors
Xiaopan Zhang et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2013)
Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
Adrienne Tin et al.
JOURNAL OF HUMAN GENETICS (2013)
Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability
Junjie Fu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization
Masayo Sakabe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation
Matthew P. Welberry Smith et al.
KIDNEY INTERNATIONAL (2013)
The SLCO (former SLC21) superfamily of transporters
Bruno Hagenbuch et al.
MOLECULAR ASPECTS OF MEDICINE (2013)
Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors
Amit K. Halder et al.
MOLECULAR DIVERSITY (2013)
The first ratiometric fluorescent probes for aminopeptidase N cell imaging
Laizhong Chen et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis
Michael Karpusas et al.
PLOS ONE (2013)
Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of a Non-Catalytic Ligandin Site
Joseph Brock et al.
PLOS ONE (2013)
Glutathione Transferase (GST)-Activated Prodrugs
Paolo Ruzza et al.
Pharmaceutics (2013)
Interaction of γ-Glutamyltranspeptidase with Ibuprofen-S-Acyl-Glutathione In Vitro and In Vivo in Human
Mark P. Grillo et al.
DRUG METABOLISM AND DISPOSITION (2013)
Designer Xanthone: An Inhibitor Scaffold for MDR-Involved Human Glutathione Transferase Isoenzyme A1-1
Ourania G. Zoi et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Characterization of Microsomal Glutathione S-Transferases MGST1, MGST2, and MGST3 in Cynomolgus Macaques
Yasuhiro Uno et al.
DRUG METABOLISM AND DISPOSITION (2013)
Glutathione transferase pi (GSTpi) expression in breast cancer: An immunohistochemical and molecular study
Bruna Victorasso Jardim et al.
ACTA HISTOCHEMICA (2012)
The first ratiometric fluorescent probe for aminopeptidase N
Laizhong Chen et al.
ANALYTICAL METHODS (2012)
An Inhibitor of Glutathione S-Transferase Omega 1 that Selectively Targets Apoptotic Cells
Nicholas J. Pace et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Glutathione-S-Transferases As Determinants of Cell Survival and Death
Kenneth D. Tew et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Association of glutathione S-transferase Ω 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-β), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water
D. M. Escobar-Garcia et al.
ARCHIVES OF TOXICOLOGY (2012)
Probing the Donor and Acceptor Substrate Specificity of the γ-Glutamyl Transpeptidase
Xin Hu et al.
BIOCHEMISTRY (2012)
New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1
Anastasia De Luca et al.
BIOCHEMISTRY (2012)
Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides
Pierre Stocker et al.
BIOCHIMIE (2012)
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors
Sebastien Albrecht et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
Li Su et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters
John I. Trujillo et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation
Qianbin Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
Megan Roth et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications
Immacolata Castellano et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Identifying and Characterizing Binding Sites on the Irreversible Inhibition of Human Glutathione S-Transferase P1-1 by S-Thiocarbamoylation
Indalecio Quesada-Soriano et al.
CHEMBIOCHEM (2012)
Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes
Mika Ito et al.
CHEMBIOCHEM (2012)
The Characteristics, Functions and Inhibitors of Three Aminopeptidases Belonging to the M1 Family
Yepeng Luan et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2012)
Susceptibility to Breast Cancer and Three Polymorphisms of GSTZ1
Iraj Saadat et al.
DNA AND CELL BIOLOGY (2012)
Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
Iva Bousova et al.
DRUG METABOLISM REVIEWS (2012)
Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1)
Hasan Othman et al.
EUROPEAN JOURNAL OF OPHTHALMOLOGY (2012)
Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein
Kirill Tsirulnikov et al.
FEBS LETTERS (2012)
Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-p-activated nitric oxide donor PABA/NO in malignant gliomas
Evangelos Kogias et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo
A. Theodoratos et al.
INTERNATIONAL JOURNAL OF OBESITY (2012)
Human hematopoietic prostaglandin D synthase inhibitor complex structures
Yuji Kado et al.
JOURNAL OF BIOCHEMISTRY (2012)
Inference of Functional Properties from Large-scale Analysis of Enzyme Superfamilies
Shoshana D. Brown et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Glutathione S-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in a Drosophila Model of Parkinson Disease
Kiyoung Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation
Yun Ding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing
Alan H. M. Wong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Mechanism of peptide hydrolysis by co-catalytic metal centers containing leucine aminopeptidase enzyme: a DFT approach
Xiaoxia Zhu et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2012)
Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate
Albert L. Shroads et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Divergent effects of compounds on the hydrolysis and transpeptidation reactions of γ-glutamyl transpeptidase
Stephanie Wickham et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2012)
Synthesis and Study of 2-(Pyrrolesulfonylmethyl)-N-arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1-1
Georgia E. Koutsoumpli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structural Insights into the Dehydroascorbate Reductase Activity of Human Omega-Class Glutathione Transferases
Huina Zhou et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Binding of GSH conjugates to π-GST: A cross-docking approach
Fabio Lannutti et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2012)
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines
Andrea Sau et al.
MOLECULAR BIOSYSTEMS (2012)
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
Mariet Allen et al.
MOLECULAR NEURODEGENERATION (2012)
Synthesis and Modifications of Phosphinic Dipeptide Analogues
Artur Mucha
MOLECULES (2012)
GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: Association hypothesis for an uncommon genetic variant
Sara Piacentini et al.
NEUROSCIENCE LETTERS (2012)
PharmGKB summary: very important pharmacogene information for GSTT1
Caroline F. Thorn et al.
PHARMACOGENETICS AND GENOMICS (2012)
Structural basis for multifunctional roles of mammalian aminopeptidase N
Lang Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
Drew J. Adams et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Design, Synthesis, and Activity Evaluation of a New 5-fluorouracil Prodrug Containing an Asn-Gly-Arg(NO2)COOCH3 Tripeptide
Yepeng Luan et al.
PROTEIN AND PEPTIDE LETTERS (2012)
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal
Kirill Tsirulnikov et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
Human cytosolic glutathione transferases: structure, function, and drug discovery
Baojian Wu et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Proteomic analysis of glutathione S-transferase isoforms in mouse liver mitochondria
Hai-Dan Sun et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2012)
Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase
James C. H. Poon et al.
XENOBIOTICA (2012)
Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis
Li Su et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Computational Evidence for the Catalytic Mechanism of Human Glutathione S-Transferase A3-3: A QM/MM Investigation
Matteo Calvaresi et al.
ACS CATALYSIS (2012)
Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies
Juan Reguera et al.
PLOS PATHOGENS (2012)
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
Qiang Ma et al.
PHARMACOLOGICAL REVIEWS (2012)
Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
Shingo Arakawa et al.
DRUG METABOLISM AND DISPOSITION (2012)
Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes
Stephanie Wickham et al.
ANALYTICAL BIOCHEMISTRY (2011)
Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport
Lin Jia et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73 (2011)
Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface
P. David Josephy et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)
The role of a membrane-bound glutathione transferase in the peroxynitrite-induced mitochondrial permeability transition pore: Formation of a disulfide-linked protein complex
Naoki Imaizumi et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)
Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism
Bing Wang et al.
BIOCHEMICAL JOURNAL (2011)
The molecular basis of aminoacylase 1 deficiency
Anke Sommer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
A novel amino-benzosuberone derivative is a picomolar inhibitor of mammalian aminopeptidase N/CD13
Carmen Maiereanu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Amino-benzosuberone: A novel warhead for selective inhibition of human aminopeptidase-N/CD13
Sebastien Albrecht et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Aminopeptidase N (CD13) as a target for cancer chemotherapy
Malin Wickstrom et al.
CANCER SCIENCE (2011)
Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation
Lorien J. Parker et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research
X. Zhang et al.
CURRENT MEDICINAL CHEMISTRY (2011)
The Many Faces of Glutathione Transferase Pi
O. Vasieva
CURRENT MOLECULAR MEDICINE (2011)
Interactions of glutathione transferases with 4-hydroxynonenal
Larissa M. Balogh et al.
DRUG METABOLISM REVIEWS (2011)
Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice
Philip G. Board et al.
DRUG METABOLISM REVIEWS (2011)
The glutathione transferase kappa family
Fabrice Morel et al.
DRUG METABOLISM REVIEWS (2011)
Sigma-class glutathione transferases
Jack U. Flanagan et al.
DRUG METABOLISM REVIEWS (2011)
Microsomal glutathione transferase 1: mechanism and functional roles
Ralf Morgenstern et al.
DRUG METABOLISM REVIEWS (2011)
The omega-class glutathione transferases: structure, function, and genetics
Philip G. Board
DRUG METABOLISM REVIEWS (2011)
Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation
Yoko Aniya et al.
DRUG METABOLISM REVIEWS (2011)
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
Larry G. Higgins et al.
DRUG METABOLISM REVIEWS (2011)
Regulation of the cardiac muscle ryanodine receptor by glutathione transferases
Angela F. Dulhunty et al.
DRUG METABOLISM REVIEWS (2011)
Glutathione transferases: a structural perspective
Aaron Oakley
DRUG METABOLISM REVIEWS (2011)
Aminopeptidase N (EC 3.4.11.2) inhibitors (2006-2010): a patent review
Li Su et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2011)
Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease
Haider Raza
FEBS JOURNAL (2011)
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
Kenneth D. Tew et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
Differential aminoacylase expression in neuroblastoma
Patrick M. Long et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin
Jian-Jun Gao et al.
INVESTIGATIONAL NEW DRUGS (2011)
Autocatalytic Cleavage of Human γ-Glutamyl Transpeptidase Is Highly Dependent on N-Glycosylation at Asparagine 95
Matthew B. West et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1
Stanley Mukanganyama et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2011)
Structural and mechanistic comparisons of the metal-binding members of the vicinal oxygen chelate (VOC) superfamily
Panqing He et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2011)
Inhibition of Glutathione S-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer Cells
Chie-Hong Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
Artur Mucha et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase zeta 1
Wenjun Li et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Preventive Effect of GGsTop, a Novel and Selective γ-Glutamyl Transpeptidase Inhibitor, on Ischemia/Reperfusion-Induced Renal Injury in Rats
Shinya Yamamoto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis
Hiroshi Yoshitake et al.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2011)
Potent and Selective Inhibitors of Glutathione S-Transferase Omega 1 That Impair Cancer Drug Resistance
Katsunori Tsuboi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Synthesis and Characterization of a Series of Highly Fluorogenic Substrates for Glutathione Transferases, a General Strategy
Jie Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo
Jian-Jun Gao et al.
MICROVASCULAR RESEARCH (2011)
Fluorescent labeling of membrane proteins on the surface of living cells by a self-catalytic glutathione S-transferase omega 1 tag
Jae-Jung Lee et al.
MOLECULAR BIOSYSTEMS (2011)
Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress
Anneke C. Blackburn et al.
LABORATORY INVESTIGATION (2011)
Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance
Katarina Johansson et al.
MOLECULAR PHARMACEUTICS (2011)
Human metabolic individuality in biomedical and pharmaceutical research
Karsten Suhre et al.
NATURE (2011)
Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to schizophrenia
Samane Nafissi et al.
PSYCHIATRY RESEARCH (2011)
MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury
Christy C. Bridges et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)
Role of MGST1 in reactive intermediate-induced injury
Courtney S. Schaffert
WORLD JOURNAL OF GASTROENTEROLOGY (2011)
Isozyme-Specific Fluorescent Inhibitor of Glutathione S-Transferase Omega 1
Junghyun Son et al.
ACS CHEMICAL BIOLOGY (2010)
High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors
Sachiko Takahashi et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2010)
Dendritic Cells Express Hematopoietic Prostaglandin D Synthase and Function as a Source of Prostaglandin D2 in the Skin
Chieko Shimura et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Glutathione transferases and development of new principles to overcome drug resistance
Andrea Sau et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia
Elsa Wiame et al.
BIOCHEMICAL JOURNAL (2010)
The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan
Malin Wickstrom et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Role of Glutathione Transferases in the Mechanism of Brostallicin Activation
Silvia Pezzola et al.
BIOCHEMISTRY (2010)
Class Pi Glutathione Transferase Unfolds via a Dimeric and Not Monomeric Intermediate: Functional Implications for an Unstable Monomer
Samantha Gildenhuys et al.
BIOCHEMISTRY (2010)
The human hGSTA5 gene encodes an enzymatically active protein
Sharda P. Singh et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)
Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1
Abeer Shokeer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)
Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1
David Balchin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Metallo-aminopeptidase inhibitors
Artur Mucha et al.
BIOCHIMIE (2010)
Activation of Rat Liver Microsomal Glutathione Transferase by Hepsin
Shinji Nakama et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
New aromatic monoesters of α-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
Renata Grzywa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Identification of very potent inhibitor of human aminopeptidase N (CD13)
Renata Grzywa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1
Samantha Gildenhuys et al.
BIOPHYSICAL CHEMISTRY (2010)
Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma
A. Santoro et al.
BRITISH JOURNAL OF CANCER (2010)
Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death
E. Laborde
CELL DEATH AND DIFFERENTIATION (2010)
Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine
Wei Zhang et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Defining the optimal biological dose of NGR-hTNF, a selective vascular targeting agent, in advanced solid tumours
Vanesa Gregorc et al.
EUROPEAN JOURNAL OF CANCER (2010)
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase
Jane E. Weber et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
NPC1L1 and cholesterol transport
Jenna L. Betters et al.
FEBS LETTERS (2010)
Multiple roles of microsomal glutathione transferase 1 in cellular protection A mechanistic study
Katarina Johansson et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Polymorphisms in the human glutathione transferase Kappa (GSTK1) promoter alter gene expression
Alison J. Shield et al.
GENOMICS (2010)
Minor Modifications of the C-terminal Helix Reschedule the Favored Chemical Reactions Catalyzed by Theta Class Glutathione Transferase T1-1
Abeer Shokeer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors
Marcin Drag et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Molecular Identification of NAT8 as the Enzyme That Acetylates Cysteine S-Conjugates to Mercapturic Acids
Maria Veiga-da-Cunha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability
Mary Cabell Jonas et al.
JOURNAL OF CELL SCIENCE (2010)
CD13 is a therapeutic target in human liver cancer stem cells
Naotsugu Haraguchi et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Dipeptide hydrolysis by the dinuclear zinc enzyme human renal dipeptidase: Mechanistic insights from DFT calculations
Rong-Zhen Liao et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2010)
Novel Oxadiazole Analogues Derived from Ethacrynic Acid: Design, Synthesis, and Structure-Activity Relationships in Inhibiting the Activity of Glutathione S-Transferase P1-1 and Cancer Cell Proliferation
Xinmei Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Development and Characterization of New Inhibitors of the Human and Mouse Hematopoietic Prostaglandin D2 Synthases
Angelika N. Christ et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases
Kaspars Tars et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Glutathione Transferase A1-1: Catalytic Importance of Arginine 15
Daniel F. A. R. Dourado et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Catalysis of Carboxypeptidase A: Promoted-Water versus Nucleophilic Pathways
Shanshan Wu et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Glutathione Transferase Classes Alpha, Pi, and Mu: GSH Activation Mechanism
Daniel F. A. R. Dourado et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
TRANSPORT OF INORGANIC MERCURY AND METHYLMERCURY IN TARGET TISSUES AND ORGANS
Christy C. Bridges et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
Inhibition of mitochondrial membrane bound-glutathione transferase by mitochondrial permeability transition inhibitors including cyclosporin A
Enkhbaatar Ulziikhishig et al.
LIFE SCIENCES (2010)
New loci associated with kidney function and chronic kidney disease
Anna Koettgen et al.
NATURE GENETICS (2010)
Genetic loci influencing kidney function and chronic kidney disease
John C. Chambers et al.
NATURE GENETICS (2010)
Relationship between serum gammaglutamyltransferase and chronic kidney disease in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006
G. Targher et al.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2010)
Overcoming the Drug Resistance in Breast Cancer Cells by Rational Design of Efficient Glutathione S-Transferase Inhibitors
Wen-Shan Li et al.
ORGANIC LETTERS (2010)
Structures of aminoacylase 3 in complex with acetylated substrates
Jennifer M. Hsieh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Common structural features of mapeg-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
Per-Johan Jakobsson et al.
PROTEIN SCIENCE (2010)
Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)
Chris P. Carron et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
Aminoacylase 1 deficiency associated with autistic behavior
Anna Tylki-Szymanska et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2010)
Characterization of a new fluorogenic substrate for microsomal glutathione transferase 1
Johan Alander et al.
ANALYTICAL BIOCHEMISTRY (2009)
Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione
Johan Alander et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties
P. David Josephy et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)
A direct spectrophotometric γ-glutamyltransferase inhibitor screening assay targeting the hydrolysis-only mode
Bjorn Vergauwen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2
Dan Liu et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta
Angelo Theodorators et al.
BIOCHEMICAL PHARMACOLOGY (2009)
RLIP76: A novel glutathione-conjugate and multi-drug transporter
Sharad S. Singhal et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Crystal Structure of Acivicin-Inhibited γ-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis
Kristin Williams et al.
BIOCHEMISTRY (2009)
Monomer-Dimer Equilibrium in Glutathione Transferases: A Critical Re-Examination
Raffaele Fabrini et al.
BIOCHEMISTRY (2009)
Glutathione Transferases Are Structural and Functional Outliers in the Thioredoxin Fold
Holly J. Atkinson et al.
BIOCHEMISTRY (2009)
Mouse aminoacylase 3: A metalloenzyme activated by cobalt and nickel
Kirill Tsirulnikov et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)
Impact of OATP transporters on pharmacokinetics
A. Kalliokoski et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases
Luca Federici et al.
CANCER RESEARCH (2009)
Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma
Yi Zhong et al.
CARCINOGENESIS (2009)
Polymorphism of DsbA-L Gene Associates with Insulin Secretion and Body Fat Distribution in Chinese Population
Fei Gao et al.
ENDOCRINE JOURNAL (2009)
Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy
I. Axarli et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)
Glutathione S-transferase π localizes in mitochondria and protects against oxidative stress
Shinji Goto et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Role of RLIP76 in doxorubicin resistance in lung cancer (Review)
Rit Vatsyayan et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2009)
Novel Role for Glutathione S-Transferase π REGULATOR OF PROTEIN S-GLUTATHIONYLATION FOLLOWING OXIDATIVE AND NITROSATIVE STRESS
Danyelle M. Townsend et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels
Mi Hee Ko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Dug1p Is a Cys-Gly Peptidase of the γ-Glutamyl Cycle of Saccharomyces cerevisiae and Represents a Novel Family of Cys-Gly Peptidases
Hardeep Kaur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A Novel, Species-specific Class of Uncompetitive Inhibitors of γ-Glutamyl Transpeptidase
Jarrod B. King et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Identification of a novel protein binding to hepatitis C virus core protein
Yun-ru Chen et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)
Increased Sensitivity of Glutathione S-Transferase P-Null Mice to Cyclophosphamide-Induced Urinary Bladder Toxicity
Daniel J. Conklin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology
Nazzareno Ballatori et al.
MOLECULAR ASPECTS OF MEDICINE (2009)
Impact of apple polyphenols on GSTT2 gene expression, subsequent protection of DNA and modulation of proliferation using LT97 human colon adenoma cells
Claudia Miene et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2009)
GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage
Astrid Petermann et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2009)
The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor
Yepeng Luan et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2009)
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes
Daniel A. Bachovchin et al.
NATURE BIOTECHNOLOGY (2009)
Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1, 3-dimethyl-1-nitrosoguanidine, and 1, 2-dichloro-4-nitrobenzene
Lars O. Hansson et al.
PROTEIN SCIENCE (2009)
Glutathione transferase A1-1: catalytic role of water
Daniel F. A. R. Dourado et al.
THEORETICAL CHEMISTRY ACCOUNTS (2009)
Mechanism of Thiol-Supported Arsenate Reduction Mediated by Phosphorolytic-Arsenolytic Enzymes
Balazs Nemeti et al.
TOXICOLOGICAL SCIENCES (2009)
Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores
Quazi Sohel Hossain et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)
Inhibition of human glutathione S-transferases by curcumin and analogues
R. Appiah-Opong et al.
XENOBIOTICA (2009)
Role of dichloroacetate in the treatment of genetic mitochondrial diseases
Peter W. Stapoole et al.
ADVANCED DRUG DELIVERY REVIEWS (2008)
S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1
Philip G. Board et al.
ANALYTICAL BIOCHEMISTRY (2008)
A high performance gel filtration chromatography method for γ-glutamyltransferase fraction analysis
Maria Franzini et al.
ANALYTICAL BIOCHEMISTRY (2008)
The influence of diet composition on phase I and II biotransformation enzyme induction
Jaime L. Rudolf et al.
ARCHIVES OF TOXICOLOGY (2008)
Probing the acyl-binding pocket of aminoacylase-1
Holger A. Lindner et al.
BIOCHEMISTRY (2008)
N-acetylamino acid utilization by kidney aminoacylase-1
Holger A. Lindner et al.
BIOCHIMIE (2008)
Development of bestatin-based activity-based probes for metallo-aminopeptidases
Michael B. Harbut et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation:: resequencing, association and in silico study
Peeter Juhanson et al.
BMC MEDICAL GENETICS (2008)
Association of γ-glutamyltransferase and risk of cancer incidence in men:: A prospective study
Alexander M. Strasak et al.
CANCER RESEARCH (2008)
An overview of cancer multidrug resistance: a still unsolved problem
H. Lage
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Chemical toxicology of reactive intermediates formed by the glutathione-dependent bioactivation of halogen-containing compounds
M. W. Anders
CHEMICAL RESEARCH IN TOXICOLOGY (2008)
Glutathione Transferase: New Model for Glutathione Activation
Daniel F. A. R. Dourado et al.
CHEMISTRY-A EUROPEAN JOURNAL (2008)
Aminopeptidase N (APN/CD13) as a Target for Anti-Cancer Agent Design
Xiaopan Zhang et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Catalysis within the lipid bilayer - structure and mechanism of the MAPEG family of integral membrane proteins
Daniel Martinez Molina et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2008)
Mammalian cytosolic glutathione transferases
Daniel F. A. R. Dourado et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2008)
Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
M. Isabel Lucena et al.
HEPATOLOGY (2008)
The human gamma-glutamyltransferase gene family
Nora Heisterkamp et al.
HUMAN GENETICS (2008)
Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs
Erica Schmuck et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
Metabolism of the Tumor Angiogenesis Inhibitor 4-(N-(S-Glutathionylacetyl)amino) phenylarsonous Acid
Pierre J. Dilda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
In vivo optical imaging of CD13/APN-expression in tumor xenografts
Angelika von Wallbrunn et al.
JOURNAL OF BIOMEDICAL OPTICS (2008)
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design
Morten Hohwy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members
Sanela Kurtovic et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: Kinetic properties and crystallographic characterisation of allelic variants
Lorien J. Parker et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Crystal structures of Escherichia coli γ-glutamyltranspeptidase in complex with azaserine and acivicin:: Novel mechanistic implication for inhibition by glutamine antagonists
Kei Wada et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Design and Synthesis of Highly Sensitive Fluorogenic Substrates for Glutathione S-Transferase and Application for Activity Imaging in Living Cells
Yuuta Fujikawa et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
NMR spectroscopy of aminoacylase 1 deficiency, a novel inborn error of metabolism
Udo F. H. Engelke et al.
NMR IN BIOMEDICINE (2008)
Amino acid transport across mammalian intestinal and renal epithelia
Stefan Broer
PHYSIOLOGICAL REVIEWS (2008)
Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden
Leiliane Paiva et al.
PHARMACOGENETICS AND GENOMICS (2008)
Glutathione S-transferase GSTT1 and GSTM1 allozymes: beyond null alleles
Jose A. G. Agundez et al.
PHARMACOGENOMICS (2008)
A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization
Meilian Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR- and control rats exposed to thiol S-conjugates of inorganic mercury
Christy C. Bridges et al.
TOXICOLOGICAL SCIENCES (2008)
Induction of Hepatic Glutathione S-Transferases in Male Mice by Prototypes of Various Classes of Microsomal Enzyme Inducers
Tamara R. Knight et al.
TOXICOLOGICAL SCIENCES (2008)
Novel function of glutathione transferase in rat liver mitochondrial membrane: Role for cytochrome c release from mitochondria
Kang Kwang Lee et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
The moonlighting enzyme CD13: old and new functions to target
Paola Mina-Osorio
TRENDS IN MOLECULAR MEDICINE (2008)
Aminopeptidase N in arterial hypertension
Robert S. Danziger
HEART FAILURE REVIEWS (2008)
Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid
Christy C. Bridges et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells
Mustafa Usta et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2007)
Glutathione S-Transferase T1 and M1:: Gene sequence variation and functional genomics
Ann M. Moyer et al.
CLINICAL CANCER RESEARCH (2007)
Constitutive mRNA expression of various glutathione S-Transferase isoforms in different tissues of mice
Tamara Raphael Knight et al.
TOXICOLOGICAL SCIENCES (2007)
Generation and functional characterization of mice with a disrupted Glutathione S-transferase, theta 1 gene
Kazunori Fujimoto et al.
DRUG METABOLISM AND DISPOSITION (2007)
Structure of the Janus protein human CLIC2
Brett A. Cromer et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Mechanisms of disease: Leukotrienes
Marc Peters-Golden et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1
Claudio Costantini et al.
BIOCHEMICAL JOURNAL (2007)
Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human γ-glutamyltranspeptidase
Roselyne Castonguay et al.
BIOCHEMISTRY (2007)
Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population
Hao Zhang et al.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2007)
Assessing exposure to atrazine and its metabolites using biomonitoring
Dana B. Barr et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2007)
Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons
Nadiya Bakhiya et al.
DRUG METABOLISM AND DISPOSITION (2007)
Acylase 1 expression in rat intestinal crypt-villus axis
Natacha Cigna et al.
CELL BIOLOGY INTERNATIONAL (2007)
Genetic pollymorphism and function of glutathione S-transferases in tumor drug resistance
Hui-Wen Lo et al.
CURRENT OPINION IN PHARMACOLOGY (2007)
The structure of membrane associated proteins in eicosanoid and glutathione metabolism as determined by electron crystallography
Hans Hebert et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Tanyel Kiziltepe et al.
BLOOD (2007)
2-hydroxychromene-2-carboxylic acid isomerase:: A kappa class glutathione transferase from Pseudomonas putida
Lawrence C. Thompson et al.
BIOCHEMISTRY (2007)
Structural characterization of dimeric murine aminoacylase III
Sergey Ryazantsev et al.
FEBS LETTERS (2007)
The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels
Yasser Abdellatif et al.
CELL CALCIUM (2007)
Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues
Yasunori Kohchi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Protection of cells from oxidative stress by microsomal glutathione transferase 1
Atchasai Siritantikorn et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1
Laura S. Busenlehner et al.
BIOCHEMISTRY (2007)
Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase
Liyou Han et al.
BIOCHEMISTRY (2007)
Multidrug resistance-associated proteins 3, 4, and 5
Piet Borst et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
Rose Hayeshi et al.
FOOD AND CHEMICAL TOXICOLOGY (2007)
Expression of glutathione S-transferase π and glutathione synthase correlates with survival in early stage non-small cell carcinomas of the lung
Timothy C. Allen et al.
HUMAN PATHOLOGY (2007)
Glutathione transferase omega 1 catalyzes the reduction of S-(Phenacyl)glutathiones to acetophenones
Philip G. Board et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2007)
Specificity of aminoacylase ill-mediated deacetylation of mercapturic acids
Debra Newman et al.
DRUG METABOLISM AND DISPOSITION (2007)
A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening
Marion Flipo et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Binding mode analysis between membrane dipeptidase and its substrates
M. Kim et al.
MOLECULAR SIMULATION (2007)
Fragment based drug discovery using fluorescence correlation spectroscopy techniques: Challenges and solutions
T. Hesterkamp et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
The structure and main functions of aminopeptidase N
Yepeng Luan et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
Ahsan N. Rizwan et al.
PHARMACEUTICAL RESEARCH (2007)
Binding structure of the leucine aminopeptidase inhibitor microginin FR1
Manuel Kraft et al.
FEBS LETTERS (2006)
Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles
R. Edward Watts et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synergistic inhibition of the enzymatic activity of aminopeptidase N by divalent metal ion chelators
Patrick M. L. Vanderheyden et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2006)
Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice:: Enzyme and arsenic species concentrations in tissues after arsenate administration
Uttam K. Chowdhury et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)
Biotransformation of glyceryl trinitrate by rat hepatic microsomal glutathione S-transferase 1
Yanbin Ji et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
γ-(monophenyl)phosphono glutamate analogues as mechanism-based inhibitors of γ-glutamyl transpeptidase
Liyou Han et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases
Yi-Ju Li et al.
NEUROBIOLOGY OF AGING (2006)
Divergent activities of human glutathione transferases in the bioactivation of azathioprine
Birgitta I. Eklund et al.
MOLECULAR PHARMACOLOGY (2006)
Structural basis for detoxification and oxidative stress protection in membranes
Peter J. Holm et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Glutathione S-transferase omega 1 and omega 2 pharmacogenomics
Baidehi Mukherjee et al.
DRUG METABOLISM AND DISPOSITION (2006)
Design, synthesis and initial in vitro evaluation of novel prodrugs for the treatment of cystinosis
RJ Anderson et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2006)
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Roger G. Deeley et al.
PHYSIOLOGICAL REVIEWS (2006)
Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase
Kosuke Aritake et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inhibition of human glutathione S-transferase omega by tocopherol succinate
A. Sampayo-Reyes et al.
BIOMEDICINE & PHARMACOTHERAPY (2006)
Expression patterns and novel splicing variants of glutathione-S-transferase isoenzymes of human lung and hepatocyte cell lines
M Bauer et al.
CELL AND TISSUE RESEARCH (2006)
Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria
Evan P. Gallagher et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Reactive nitrogen species derived activation of rat liver microsomal glutathione S-transferase
Naoki Imaizumi et al.
LIFE SCIENCES (2006)
Is fluoroacetate-specific defluorinase a glutathione S-transferase?
LQ Tu et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2006)
β-lipoprotein- and LDL-associated serum γ-glutamyltransferase in patients with coronary atherosclerosis
A Paolicchi et al.
ATHEROSCLEROSIS (2006)
Polymorphisms in the human glutathione transferase zeta promoter
Yu-Yan Fang et al.
PHARMACOGENETICS AND GENOMICS (2006)
Up-regulation of γ-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than an inhibitory effect on mitochondrial complex I activity:: Implications for Parkinson's disease
Shankar J. Chinta et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Crystal structures of γ-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate
T Okada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher
I Mohri et al.
JOURNAL OF NEUROSCIENCE (2006)
Glutathione S-transferase (GST) inhibitors
N Mathew et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2006)
The human organic anion transporter 3 (OAT3; SLC22A8):: genetic variation and functional genomics
AR Erdman et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a
Y Patskovsky et al.
BIOCHEMISTRY (2006)
Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase
M Cappiello et al.
BIOCHEMISTRY (2006)
Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism
JO Sass et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Probing the catalytic center of porcine aminoacylase 1 by site-directed mutagenesis, homology modeling and substrate docking
ZG Liu et al.
JOURNAL OF BIOCHEMISTRY (2006)
Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer
LC Thompson et al.
BIOCHEMISTRY (2006)
C/EBPα-dependent induction of glutathione S-transferase ζ/maleylacetoacetate isomerase (GSTζ/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes
QA Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Metabonomics and biomarker discovery:: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis
S Wagner et al.
ANALYTICAL CHEMISTRY (2006)
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways
AC Blackburn et al.
MOLECULAR PHARMACOLOGY (2006)
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix
E Grahn et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
The intersubunit lock-and-key motif in human glutathione transferase A1-1:: role of the key residues Met51 and Phe52 in function and dimer stability
CS Alves et al.
BIOCHEMICAL JOURNAL (2006)
Expression of γ-glutamyltransferase in cancer cells and its significance in drug resistance
A Pompella et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant
K Tars et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays
Wenhui Zhou et al.
CHEMICAL COMMUNICATIONS (2006)
Gamma-glutamyltransferase as a cardiovascular risk factor
Michele Emdin et al.
EUROPEAN HEART JOURNAL (2006)
Advance in antitumor agents targeting glutathione-S-transferase
GS Zhao et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal
X Guo et al.
DRUG METABOLISM AND DISPOSITION (2006)
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
E Cesareo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Aminoacylase I deficiency: A novel inborn error of metabolism
RN Van Coster et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Glutathione transferases: new functions
AJ Oakley
CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)
Serum γ-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population
C Meisinger et al.
JOURNAL OF INTERNAL MEDICINE (2005)
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate
I Cacciatore et al.
AMINO ACIDS (2005)
γ-glutamyltransferase as a risk factor for cardiovascular disease mortality -: An epidemiological investigation in a cohort of 163,944 Austrian adults
E Ruttmann et al.
CIRCULATION (2005)
Characterization of the fluoroacetate detoxication enzymes of rat liver cytosol
LQ Tu et al.
XENOBIOTICA (2005)
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma
C Röcken et al.
JOURNAL OF CLINICAL PATHOLOGY (2005)
An electron-sharing network involved in the catalytic mechanism is functionally conserved in different glutathione transferase classes
P Winayanuwattikun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Thioredoxin-like domain of human κ class glutathione transferase reveals sequence homology and structure similarity to the θ class enzyme
J Li et al.
PROTEIN SCIENCE (2005)
Serum γ-glutamyltransferase within its normal concentration range is related to the presence of diabetes and cardiovascular risk factors
DJ Kim et al.
DIABETIC MEDICINE (2005)
Catabolism of intracellular N-terminal acetylated proteins: involvement of acylpeptide hydrolase and acylase
J Perrier et al.
BIOCHIMIE (2005)
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases -: Mechanism of action of potential anticancer drugs
G Ricci et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases
EM Schmuck et al.
PHARMACOGENETICS AND GENOMICS (2005)
Differential roles of 3H-1,2-dithiole-3-thione-induced glutathione, glutathione S-transferase and aldose reductase in protecting against 4-hydroxy-2-nonenal toxicity in cultured cardiomyocytes
YB Li et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
The target of ezetimibe is Niemann-Pick Cl-Like 1 (NPC1L1)
M Garcia-Calvo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mode of action of bi- and trinuclear zinc hydrolases and their synthetic analogues
J Weston
CHEMICAL REVIEWS (2005)
Maackiain 3-O-(6'′O-malonyl-β-D-glucopyranoside) from Oudneya africana, a powerful inhibitor of porcine kidney acylase I
P Stocker et al.
BIOCHIMIE (2005)
Nuclear localisation of glutathione S-transferase π is an evaluation factor for drug resistance in gynaecological cancers
Y Soh et al.
CLINICAL ONCOLOGY (2005)
The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases
S Mahajan et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis
JS Hwa et al.
JOURNAL OF KOREAN MEDICAL SCIENCE (2005)
Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a minireview
V Haufroid et al.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2005)
Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates
A Shokeer et al.
BIOCHEMICAL JOURNAL (2005)
Organic anion transporter (Slc22a) family members as mediators of toxicity
DH Sweet
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Bioinformatic and enzymatic characterization of the MAPEG superfamily
A Bresell et al.
FEBS JOURNAL (2005)
Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
SY Park et al.
ARCHIVES OF PHARMACAL RESEARCH (2005)
A water sluice is generated in the active site of bovine lens leucine aminopeptidase
S Erhardt et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance
WH Ang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Microsomal glutathione S-transferase 1 in the retinal pigment epithelium:: Protection against oxidative stress and a potential role in aging
A Maeda et al.
BIOCHEMISTRY (2005)
Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane
W Kramer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Elevated plasma cysteinylglycine levels caused by cilastatin-associated antibiotic treatment
S Badiou et al.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2005)
Zinc hydrolases: the mechanisms of zinc-dependent deacetylases
M Hernick et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug
VJ Findlay et al.
MOLECULAR PHARMACOLOGY (2004)
Gene and protein characterization of the human glutathione S-transferase Kappa and evidence for a peroxisomal localization*
F Morel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry
J Lengqvist et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Characterization of a class alpha glutathione-S-transferase with glutathione peroxidase activity in human liver microsomes
KS Prabhu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
Structural characterization, tissue distribution, and functional expression of murine aminoacylase III
A Pushkin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Functional role of the lock and key motif at the subunit interface of glutathione transferase P1-1
UM Hegazy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase
T Inoue et al.
JOURNAL OF BIOCHEMISTRY (2004)
New role for leucyl aminopeptidase in glutathione turnover
M Cappiello et al.
BIOCHEMICAL JOURNAL (2004)
Mapping enzyme active sites in complex proteomes
GC Adam et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates
EC Callaway et al.
CANCER LETTERS (2004)
Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography
F Jardinaud et al.
BIOCHIMIE (2004)
The acetyl-CoA transporter family SLC33
Y Hirabayashi et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Parallel evolutionary pathways for glutathione transferases: Structure and mechanism of the mitochondrial class kappa enzyme rGSTK1-1
JE Ladner et al.
BIOCHEMISTRY (2004)
Membrane bound members of the M1 family: More than aminopeptidases
AL Albiston et al.
PROTEIN AND PEPTIDE LETTERS (2004)
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1
LS Busenlehner et al.
BIOCHEMISTRY (2004)
Binding and kinetic mechanisms of the zeta class glutathione transferase
G Ricci et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structural basis for catalytic differences between α class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide
SV Singh et al.
BIOCHEMISTRY (2004)
Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis
A Schneider et al.
JOURNAL OF GASTROENTEROLOGY (2004)
Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of Alpha, Mu, and Pi class glutathione transferases
CEL Lim et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
H Kölsch et al.
NEUROLOGY (2004)
Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity
YJ Gu et al.
BIOCHEMISTRY (2004)
Kinetic characterization of thiolate anion formation and chemical catalysis of activated microsomal glutathione transferase 1
R Svensson et al.
BIOCHEMISTRY (2004)
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase
H Gurulingappa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Synthesis of S-alkyl L-homocysteine analogues of glutathione and their kinetic studies with γ-glutamyl transpeptidase
C Lherbet et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
The rat kidney acylase 1. Evidence for a new cDNA form and comparisons with the porcine intestinal enzyme
J Perrier et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2004)
N-acetylation of the glutamate residue of intact glutathione conjugates in rats: A novel pathway for the metabolic processing of thiol adducts of xenobiotics
WJ Yin et al.
DRUG METABOLISM AND DISPOSITION (2004)
MITF is necessary for generation of prostaglandin D2 in mouse mast cells
E Morii et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity
PK Smitherman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Aminoacylase 1 is a sphingosine kinase 1-interacting protein
M Maceyka et al.
FEBS LETTERS (2004)
Probing the stereochemistry of the active site of gamma-glutamyl transpeptidase using sulfur derivatives of L-glutamic acid
C Lherbet et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
GenePaint.org: an atlas of gene expression patterns in the mouse embryo
A Visel et al.
NUCLEIC ACIDS RESEARCH (2004)
Is serum gamma glutamyltransferase a marker of oxidative stress?
DH Lee et al.
FREE RADICAL RESEARCH (2004)
A novel antioxidant role for ligandin behavior of glutathione S-transferases:: Attenuation of the photodynamic effects of hypericin
WD Lu et al.
BIOCHEMISTRY (2004)
Biotransformation of methyl parathion by glutathione S-transferases
EL Abel et al.
TOXICOLOGICAL SCIENCES (2004)
Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain:: identification of the promoter region and a comprehensive examination of tissue expression
MJ Kelner et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2004)
Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form
BT Ning et al.
PHARMACOGENETICS (2004)
Directed enzyme evolution guided by multidimensional analysis of substrate-activity space
AK Larsson et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2004)
Promoter polymorphisms in glutathione-S-transferase genes affect transcription
CA Guy et al.
PHARMACOGENETICS (2004)
Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa
RE Thomson et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2004)
Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases
A Robinson et al.
BIOCHEMICAL JOURNAL (2004)
Molecular and catalytic properties of three rat leukotriene C4 synthase homologs
O Schröder et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family
HA Lindner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The role of glutathione-S-transferase in anti-cancer drug resistance
DM Townsend et al.
ONCOGENE (2003)
Rat kidney acylase I: further characterisation and mutation studies on the involvement of Glu 147 in the catalytic process
A Durand et al.
BIOCHIMIE (2003)
Clarification of the role of key active site residues of glutathione transferase Zeta/maleylacetoacetate isomerase by a new spectrophotometric technique
PG Board et al.
BIOCHEMICAL JOURNAL (2003)
Genetic variation in genes associated with arsenic metabolism:: Glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans
LZ Yu et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2003)
Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin
JS Shim et al.
CHEMISTRY & BIOLOGY (2003)
Hematopoietic prostaglandin D synthase
Y Kanaoka et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2003)
Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase
IR Jowsey et al.
BIOCHEMICAL JOURNAL (2003)
Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells
M Zaitsu et al.
EUROPEAN RESPIRATORY JOURNAL (2003)
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity
J Grembecka et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Prognostic significance of glutathione S-transferase-Pi in invasive breast cancer
JX Huang et al.
MODERN PATHOLOGY (2003)
Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70
MA Robin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing
RE Laliberte et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of two additional members of the membrane-bound dipeptidase family
GM Habib et al.
FASEB JOURNAL (2003)
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells
AS Don et al.
CANCER CELL (2003)
Probing the dimeric structure of porcine aminoacylase 1 by mass spectrometric and modeling procedures
C D'Ambrosio et al.
BIOCHEMISTRY (2003)
Mechanism of metal activation of human hematopoietic prostaglandin D synthase
T Inoue et al.
NATURE STRUCTURAL BIOLOGY (2003)
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with γ-glutamyltranspeptidase
C Lherbet et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
A substrate variant as a high-affinity, reversible inhibitor: Insight from the X-ray structure of cilastatin bound to membrane dipeptidase
TP Smyth et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Characterization of the human Omega class glutathione transferase genes and associated polymorphisms
AK Whitbread et al.
PHARMACOGENETICS (2003)
Gamma-glutamyltransferase and diabetes - a 4 year follow-up study
DH Lee et al.
DIABETOLOGIA (2003)
Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat
J Alary et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2003)
Design, synthesis and evaluation of new RDP inhibitors
H Gurulingappa et al.
TETRAHEDRON LETTERS (2003)
Assessing the health risks following environmental exposure to hexachlorobutadiene
T Green et al.
TOXICOLOGY LETTERS (2003)
Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn)
T Tanaka-Kagawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver
C Jösch et al.
BIOLOGICAL CHEMISTRY (2003)
Interaction of cysteine conjugates with human and rabbit organic anion transporter 1
CE Groves et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Polymorphisms in the human monomethylarsonic acid (MMA(V)) reductase/hGSTO1 gene and changes in urinary arsenic profiles
LL Marnell et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2003)
Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases
R Svensson et al.
ANALYTICAL BIOCHEMISTRY (2002)
Mercapturic acids in the biological monitoring of occupational exposure to chemicals
L Perbellini et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2002)
Metalloaminopeptidases: Common functional themes in disparate structural surroundings
WT Lowther et al.
CHEMICAL REVIEWS (2002)
Mapping of the active site of rat kidney γ-glutamyl transpeptidase using activated esters and their amide derivatives
R Castonguay et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta
WB Anderson et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2
TA Simmons-Willis et al.
BIOCHEMICAL JOURNAL (2002)
1.3-Å resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site
I Le Trong et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2002)
From glutathione transferase to pore in a CLIC
BA Cromer et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2002)
The reaction mechanism of bovine lens leucine aminopeptidase
G Schürer et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2002)
Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase
PL Pettersson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress
H Raza et al.
BIOCHEMICAL JOURNAL (2002)
Identification and characterization of GSTT3, a third murine Theta class glutathione transferase
M Coggan et al.
BIOCHEMICAL JOURNAL (2002)
Crystal structure of human renal dipeptidase involved in β-lactam hydrolysis
Y Nitanai et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Structure-activity relationship for the biotransformation of haloalkenes by rat liver microsomal glutathione transferase 1
LJ Jolivette et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
γ-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo
B Han et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
GC Adam et al.
NATURE BIOTECHNOLOGY (2002)
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
H Motohashi et al.
GENE (2002)
Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1)
HBM Lantum et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
The human glutathione transferase alpha locus:: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter
F Morel et al.
PHARMACOGENETICS (2002)
Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues
HBM Lantum et al.
DRUG METABOLISM AND DISPOSITION (2002)
Structure-based design and synthesis of dipeptide analogues as new inhibitors of leucine aminopeptidase
J Grembecka et al.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2002)
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3
AS Johansson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The 3-D structure of microsomal glutathione transferase 1 at 6 Å resolution as determined by electron crystallography of p22121 crystals
PJ Holm et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2002)
Tissue distribution of and species differences in deacetylation of N-acetyl-L-cysteine and immunohistochemical localization of acylase I in the primate kidney
A Yamauchi et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2002)
Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system
H Hoensch et al.
GUT (2002)
Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro:: Interindividual variability in N-acetylation, N-deacetylation, and β-lyase-catalyzed metabolism
TG Altuntas et al.
DRUG METABOLISM AND DISPOSITION (2002)
The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitro sourea
S Lien et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity
PJ Sherratt et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2002)
Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance
D Burg et al.
DRUG METABOLISM REVIEWS (2002)
Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system
SO Fetissov et al.
NEUROSCIENCE (2002)
Glycosyl-phosphatidytinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo
SW Park et al.
KIDNEY & BLOOD PRESSURE RESEARCH (2002)
Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro
TG Altuntas et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2001)
Immunohistological analysis of glutathione transferase A4 distribution in several human tissues using a specific polyclonal antibody
F Desmots et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2001)
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-Å resolution
SJ Harrop et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase
AC Blackburn et al.
PHARMACOGENETICS (2001)
Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1
JM Pombrio et al.
MOLECULAR PHARMACOLOGY (2001)
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