Journal
BRAIN
Volume 139, Issue -, Pages 2855-2863Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/aww219
Keywords
neuroophthalmology; neuroimmunology; clinical trials; multiple sclerosis biomarkers; imaging
Categories
Funding
- Kompetenznetz Multiple Sklerose KKNMS
- Technische Universitat Munchen
- Deutsche Forschungsgemeinschaft DFG [TR 128]
- Gemeinnutzige Hertie-Stiftung
- Deutsche Forschungsgemeinschaft DFG
- DFG [TR 128, SFB 1054]
- European Research Council ERC [CoG 647215]
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Assessment of inflammatory disease activity during multiple sclerosis is crucial for selecting appropriate disease- modifying therapies. Previous studies suggested that the retinal inner nuclear layer reflects inflammatory disease severity within the central nervous system. In our study, correlations of longitudinal retinal layer changes as measured by retinal optical coherence tomography with ongoing disease activity were evaluated in 108 multiple sclerosis patients without therapy, on first- line therapy, or on second- line therapy. Healthy subjects served as controls. Inner nuclear layer volume at baseline correlated positively with paraclinical disease activity during the subsequent 12 months. Longitudinal thinning of the inner nuclear layer and thickening of total macular volume were associated with reduced inflammatory disease activity. Reduction in inner nuclear layer volume after 1 year indicated efficient control of inflammatory disease activity including ` no evidence of disease activity'. In conclusion, the retinal inner nuclear layer could serve as biomarker to monitor sustained control of autoimmune central nervous system inflammation by therapeutic interventions.
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