Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 186, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.110685
Keywords
Lignin; Cholesterol; Hydrophobic; Nanoparticles; Drug delivery
Funding
- North Carolina State University
- National Natural Science Foundation of China [31470602, 31670595, 31770628]
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Two fractions of kraft lignin of low and high molecular weight were reacted with cholesteryl chloroformate (Chol.Cl) to produce a modified lignin that demonstrated very high hydrophobicity. Surprisingly, both fractions displayed discernible melting points as opposed to the starting lignin. The suspension in water also gave rise to nanoparticles that displayed sizes in the range of 200-500 nm that were shown to satisfactorily load and release folic acid, a representative hydrophobic molecule, within the context of drug delivery.
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