Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 184, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.110496
Keywords
Green nanomedicine; Gold nanoparticle; Medicinal plant; Plasmonic photothermal therapy; Hyperthermia
Funding
- BPI France
- Europe (FEDER)
- Regional Council of La Reunion
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A greener approach for the design of surface plasmon resonant gold nanoparticles has been obtained with a hydrosoluble fraction of an endemic asteraceae medicinal plant. This medicinal plant is originated from Indian Ocean and demonstrates its bioreducing activity in the design of stable green nanomedicine in aqueous media. This article describes the preclinical assessment of the efficacy of these novel nanocandidates on murine model by intratumoral and intravenous injections. It definitely demonstrates two key points in the treatment of cancer: 1) optimization of the tumor microenvironment targeting by specific ligands for a limited damage on healthy tissue, 2) the need to screen the specific irradiation dose (time, power) taking into account the type of tumor.
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