TNFα Blockade in Checkpoint Inhibition: The Good, the Bad, or the Ugly?

The impact on survival of steroids and TNF alpha blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a large national database. Using steroids was associated with better survival than the use of TNF alpha-blocking antibodies such as infliximab.