Journal
CLINICA CHIMICA ACTA
Volume 499, Issue -, Pages 118-122Publisher
ELSEVIER
DOI: 10.1016/j.cca.2019.09.002
Keywords
Exosomes; Microvesicles; Vascular calcification; Chronic kidney disease; Atherosclerosis
Categories
Funding
- National Natural Science Foundation of China [81670424, 81900424]
- Key Scientific Research Fund of Hunan Provincial Education Department [15A166]
- Scientific Research Fund of Hunan Provincial Health and Family Planning Commission [B2016087, B20180058, B20180874]
- National Natural Science Foundation of Hunan Province [2018112345, 2019JJ40258, 2019JJ50502, 2015JJ2118]
- Scientific Research Fund of Security Bureau of China [hunan-0013-2016AQ]
- Hunan Science and Technology Department Project [2017JJ3141]
- Changsha Science and Technology Bureau Project [kql 706026]
- Innovation of College Students in Hunan Province [S201910555035]
- project of Research Study and Innovative Experiment Program for College Students in University of South China [2017XJXZ031, 2017XJYZ048, 2018XJXZ375, X2019131]
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Vascular calcification is associated with adverse cardiovascular events that increase the risk of cardiovascular death. Unfortunately, the pathogenesis of vascular calcification is complex and incompletely understood. As important intercellular signaling molecules, the role of extracellular vesicles (EVs) in vascular calcification has attracted wide attention in recent years. This review will briefly describe the role of EVs (mainly including exosomes and microvesicles) in the process of vascular wall calcification focusing on the specific mechanisms of smooth muscle cell (SMC) differentiation and calcium-phosphorus balance to illustrate the relationship between EVs and vascular calcification. It is likely that EVs may be prognostic markers in some cardiovascular diseases and have potential therapeutic potential.
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